Evidence map›Paper›PMID 41770779›Full record

ArticlePloS one2026

Evolving threats: Leveraging C. elegans to decode the virulence profiles of highly related environmental Salmonella Newport isolates.

Christina M Ferreira, Mirae Choe, Bella Wayhs, Julie A Haendiges, Robert Literman, Jianghong Meng, Arjuman Ghazi, Rebecca L Bell

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Christina M FerreiraOffice of Applied Microbiology and Technology, Office of Laboratory Operations and Applied Science, Human Foods Program, United States Food and Drug Administration, College Park, Maryland, United States of America.ORCID https://orcid.org/0000-0001-6018-5885
Mirae ChoeDepartments of Pediatrics and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center, One Children's Hospital Drive, Pittsburgh, Pennsylvania, United States of America.ORCID https://orcid.org/0009-0000-4833-9327
Bella WayhsDepartments of Pediatrics and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center, One Children's Hospital Drive, Pittsburgh, Pennsylvania, United States of America.
Julie A HaendigesOffice of Applied Microbiology and Technology, Office of Laboratory Operations and Applied Science, Human Foods Program, United States Food and Drug Administration, College Park, Maryland, United States of America.
Robert LitermanDivision of Surveillance and Data Integration, Office of Surveillance Strategy & Risk Prioritization, Human Foods Program, United States Food and Drug Administration, College Park, Maryland, United States of America.ORCID https://orcid.org/0000-0002-1784-0407
Jianghong MengDepartment of Nutrition and Food Science, University of Maryland - College Park, College Park, Maryland, United States of America.
Arjuman GhaziDepartments of Pediatrics and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center, One Children's Hospital Drive, Pittsburgh, Pennsylvania, United States of America.
Rebecca L BellOffice of Applied Microbiology and Technology, Office of Laboratory Operations and Applied Science, Human Foods Program, United States Food and Drug Administration, College Park, Maryland, United States of America.ORCID https://orcid.org/0000-0002-7469-1946

Funding

FDA HHS U01 FD001418
6 · The paper itself

Abstract

Salmonella enterica subspecies enterica, particularly serovar Newport, remains a leading cause of foodborne illnesses in the United States, implicated in numerous outbreaks associated with a diverse array of food products. This study systematically investigates the virulence of five distinct S. Newport isolates, characterized by varying patterns of pulse-field gel electrophoresis (PFGE) molecular-diagnostic subtyping, using the nematode Caenorhabditis elegans as a host model organism. We conducted viability assays on C. elegans to evaluate how these isolates affect nematode survival. The selected bacterial strains, chosen for their historical significance in foodborne outbreaks yet isolated form environmental sources, were previously sequenced to provide a comprehensive genomic framework. A notable focus of our research was on the nearly genetically identical PFGE types Newport-61 and the Newport-1015 isolates, which differ by a 1.7 Mb genomic inversion. C. elegans survival assays in response to pathogenic-strain infections revealed that one Newport-1015 and the Newport-61 isolates were particularly more virulent compared to other isolates tested. These findings enhance our understanding of the pathogenic potential of environmental S. Newport and highlight the need to understand the regulatory mechanisms that contribute to virulence capacity.

Indexed as

Caenorhabditis elegansSalmonella entericaAnimalsElectrophoresis, Gel, Pulsed-FieldVirulence

Identifiers

PMID41770779
PMCPMC12952584

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.