Evidence map›Paper›PMID 41770920›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic N

Junhua Niu, Haoze Yu, Yongqiang Liu, Lanheng Nie, Bei Nan, Wenxin Zhang, Ni Song, Shaoqin Rong, Dan Zhou, Shan Gao

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junhua Niu *Key Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.ORCID 0009-0003-9768-2174
Haoze Yu *Key Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.ORCID 0009-0001-4509-7585
Yongqiang LiuKey Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.
Lanheng NieKey Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.ORCID 0009-0002-5625-0474
Bei NanKey Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.ORCID 0009-0002-6279-4179
Wenxin ZhangInstitute of Biomedical Research, Yunnan University, Kunming 650500, China.ORCID 0009-0002-5886-3258
Ni SongKey Laboratory of Marine Medicine, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Shaoqin RongKey Laboratory of Epigenetic Regulation and Intervention, Shanghai Key Laboratory of Molecular Andrology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Dan ZhouCenter for Medical Research and Innovation, Shanghai Pudong Hospital, Institutes of Biomedical Sciences, Medical College of Fudan University, Shanghai 201399, China.ORCID 0000-0002-2306-3456
Shan GaoKey Laboratory of Evolution and Marine Biodiversity and Institute of Evolution and Marine Biodiversity, Chinese Ministry of Education, Ocean University of China, Qingdao 266003, China.ORCID 0000-0003-2083-2616

Funding

MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 202561040MOST | National Natural Science Foundation of China (NSFC) 32125006MOST | National Natural Science Foundation of China (NSFC) 32370625| Natural Science Foundation of Shandong Province () ZR2024ZD40
6 · The paper itself

Abstract

DNA N

Indexed as

AdenineAlkB EnzymesProtozoan ProteinsTetrahymena thermophilaDNA MethylationTranscription Initiation Site6-methyladenineAdenineAlkB EnzymesProtozoan ProteinsAlkB familydemethylaseDNA N6-methyladenine (6mA)Tetrahymenaunicellular eukaryote

Identifiers

PMID41770920
PMCPMC12974511

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.