Evidence map›Paper›PMID 41771587›Full record

ArticlePediatric obesity2026

Specific Fat Depots and Cardiometabolic Risk and Insulin Resistance in Children With Obesity.

Cristina Cadenas-Sanchez, María Medrano, Maddi Osés, Mara Concepción, Rafael Cabeza, Arantxa Villanueva, Fernando Idoate, Michael I Goran, Jonatan R Ruiz, Idoia Labayen

Abstract read
In one paragraph

Article in Pediatric obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cristina Cadenas-SanchezDepartment of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.ORCID https://orcid.org/0000-0002-4513-9108
María MedranoCIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain.
Maddi OsésELIKOS Research Group, Department of Health Sciences, Institute for Sustainability & Food Chain Innovation, Public University of Navarra, Pamplona, Spain.
Mara ConcepciónIdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Rafael CabezaDepartment of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain.
Arantxa VillanuevaIdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Fernando IdoateRadiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarra, Pamplona, Spain.
Michael I GoranDivision of Endocrinology, Diabetes and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, California, Los Angeles, USA.ORCID https://orcid.org/0000-0002-6897-6961
Jonatan R RuizDepartment of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Idoia LabayenCIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain.

Funding

Development of the Government of Navarra 0011-1365-2019-000085EU Fondos Estructurales de la Unión Europea (FEDER) funds ("Una manera de hacer Europa")European Association for the Study of Obesity-Novo Nordisk Foundation NNF23SA0083955European Union's Horizon 2020 Research and Innovation Programme, Marie Sklodowska Curie 101028929Spanish Ministry of Health "Fondos de Investigación Sanitaria del Instituto de Salud Carlos III" PI13/01335Spanish Ministry of Industry and Competitiveness DEP2016-78377-R
6 · The paper itself

Abstract

backgroundIn children, the impact of specific fat depots, particularly ectopic depots, on cardiometabolic health has been scarcely investigated. Therefore, we aimed to investigate the associations of various specific fat depots with cardiometabolic risk and insulin resistance in children with overweight/obesity.

methodsOne hundred fourteen children with overweight/obesity (54.4% girls, 10.6 ± 1.1 years) were included. Fat depots including abdominal visceral (VAT), subcutaneous (ASAT), and intermuscular (IMAAT) adipose tissue, lumbar spine bone marrow, hepatic and pancreatic fat were measured using magnetic resonance imaging. Cardiometabolic risk factors (blood pressure, triglycerides, high-density lipoprotein cholesterol, glucose and insulin) were assessed, and age- and sex-reference based cardiometabolic risk score and insulin resistance were calculated.

resultsIn univariate analysis, VAT, ASAT, IMAAT and hepatic fat were significantly associated with cardiometabolic risk score (β = 0.308-0.526, p ≤ 0.001) and insulin resistance (β = 0.227-0.412, p < 0.05). However, after adjusting for other fat variables, VAT was the only fat depot independently associated with cardiometabolic risk score (β = 0.450, p < 0.001), while ASAT was the only fat depot independently associated with insulin resistance (β = 0.393, p < 0.001). Hepatic fat did not show an independent association with either cardiometabolic risk score or insulin resistance (p ≥ 0.256).

conclusionIn this population, VAT and ASAT appear to be independent predictors of cardiometabolic risk and insulin resistance, respectively.

Indexed as

Adipose TissueCardiovascular DiseasesInsulin ResistancePediatric ObesityAdolescentCardiometabolic Risk FactorsChildCross-Sectional StudiesFemaleHumansIntra-Abdominal FatMagnetic Resonance ImagingMaleRisk Factorshepatic fatintermuscular fatlumbar spine bone marrow fatpancreatic fatsubcutaneous fatvisceral fat

Identifiers

PMID41771587
PMCPMC12953010

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.