Evidence map›Paper›PMID 41771799›Full record

ArticleBioFactors (Oxford, England)

Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid-β: Integrated Biochemical and Computational Analysis.

Rosalia Pellitteri, Cristina Tomasella, Maria Assunta Chiacchio, Matteo Pappalardo, Laura Legnani, Michela Spatuzza, Alessandro Massaro, Salvatore Guccione, Agatina Campisi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioFactors (Oxford, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rosalia PellitteriInstitute for Biomedical Research and Innovation (IRIB), National Research Council, Catania, Italy.
Cristina TomasellaPolo Universitario Dell'annunziata, Dottorato in Scienze Veterinarie, University of Messina, Messina, Italy.
Maria Assunta ChiacchioDepartment of Drug and Health Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
Matteo PappalardoDepartment of Drug and Health Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
Laura LegnaniDepartment of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy.
Michela SpatuzzaInstitute for Biomedical Research and Innovation (IRIB), National Research Council, Catania, Italy.
Alessandro MassaroDepartment of Biological, Chemical, and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.ORCID https://orcid.org/0009-0001-6182-8608
Salvatore GuccioneDepartment of Drug and Health Sciences, Section of Biochemistry, University of Catania, Catania, Italy.
Agatina CampisiDepartment of Drug and Health Sciences, Section of Biochemistry, University of Catania, Catania, Italy.ORCID https://orcid.org/0000-0002-9808-4681

Funding

PIA.CE. RI 2020-2022 57722172121
6 · The paper itself

Abstract

Herein, we adopted a dual approach combining molecular modeling and biological studies, in order to assess the interaction between four selected natural antioxidants (NAs; berberine, curcumin, astaxanthin, indicaxanthin) and tissue transglutaminase (TG2) levels both in the absence and in the presence of full native peptide of amyloid-β (Aβ). Docking studies were performed to ascertain the binding affinity of NAs against the TG2 closed, Ca

Indexed as

Amyloid beta-PeptidesAntioxidantsGTP-Binding ProteinsPeptide FragmentsTransglutaminasesAnimalsApoptosisCell SurvivalCurcuminMolecular Docking SimulationOlfactory BulbProtein Glutamine gamma Glutamyltransferase 2RatsReactive Oxygen SpeciesAmyloid beta-Peptidesamyloid beta-protein (1-42)amyloid beta-protein (25-35)AntioxidantsCurcuminGTP-Binding ProteinsPeptide FragmentsProtein Glutamine gamma Glutamyltransferase 2Reactive Oxygen SpeciesTgm2 protein, ratTransglutaminasesdocking studiesnatural antioxidantsneuroprotectionOlfactory Ensheathing Cellstissue transglutaminase

Identifiers

PMID41771799
PMCPMC12953212

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.