Evidence map›Paper›PMID 41772140›Full record

Reviewnpj metabolic health and disease2026

Lifestyle strategies and mechanistic implications for slowing neurodegeneration.

Jordan A Gunning, Mario I Hernandez, Behzad Gudarzi, Hana M Roushdy, Yonas E Geda, Susan B Racette

Abstract readReview
In one paragraph

Review in npj metabolic health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jordan A GunningCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Mario I HernandezCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Behzad GudarziCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Hana M RoushdyCollege of Integrative Sciences and Arts, Arizona State University, Tempe, AZ, USA.
Yonas E GedaDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Susan B RacetteCollege of Health Solutions, Arizona State University, Phoenix, AZ, USA. Susan.Racette@asu.edu.

Funding

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and AgingR01AG071717 · NIA · TUFTS UNIVERSITY BOSTON · PI Sai Krupa Das, Susan Beth Racette · 2021 to 2026
$6.3M
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trialR33HL155858 · NHLBI · WASHINGTON UNIVERSITY · PI ANDREW R COGGAN, LINDA Ruth PETERSON · 2023 to 2026
$2.9M
The Inorganic Nitrate and eXercise performance in Heart Failure (iNIX-HF): - a phase II clinical trialR61HL155858 · NHLBI · WASHINGTON UNIVERSITY · PI COGGAN, ANDREW R, PETERSON, LINDA RUTH · 2022 to 2022
$804k
NHLBI NIH HHS R33 HL155858NIA NIH HHS R01AG071717NIDDK NIH HHS R61HL155858
6 · The paper itself

Abstract

There is growing evidence that lifestyle habits influence neurodegenerative disease risk. Dietary strategies and exercise are among the most important lifestyle approaches to promote brain health. This review highlights the primary mechanisms by which three dietary approaches (metabolic switching, calorie restriction, high diet quality) and exercise may promote neuroprotection and inhibit neurodegeneration. Neuroprotective mechanisms induced by a healthful lifestyle include reduced inflammation, increased autophagy, neurogenesis, decreased neuronal cell death, and attenuation of pathological protein burden.

Identifiers

PMID41772140
PMCPMC12954078

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.