Evidence map›Paper›PMID 41772203›Full record

ArticleScience China. Life sciences2026

Light-at-night exposure drives myopia via melanopsin signalling.

Jiaxin Li, Congying Li, Meijun Wang, Jianjun Meng, Jiajia Dang, Ying Huang, Di Shi, Xinyu Li, Shan Cai, Tianli Peng and 9 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Mesopic Illumination in Natural Environments: Implications for Myopia Research.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jiaxin Li *National Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Congying Li *Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Meijun WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Jianjun MengThe First Affiliated Hospital of University of Science and Technology of China, Hefei, 230001, China.
Jiajia DangNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Ying HuangBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Di ShiNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Xinyu LiBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Shan CaiNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Tianli PengBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Yunfei LiuNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Yuting KangBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China.
Tianyu HuangNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China.
Lipo GuoChangping Health Education Center for Primary and Secondary Schools, Beijing, 102299, China.
Zhaocang YuBeijing Tongzhou District Primary and Secondary School Health Care Institute, Beijing, 101100, China.
Haihua ChenDongcheng Primary and Secondary School Health Care Center, Beijing, 100010, China.
Ningli WangBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China. wningli@vip.163.com.
Yi SongNational Health Commission Key Laboratory of Reproductive Health, Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, 100191, China. songyi@bjmu.edu.cn.
Shi-Ming LiBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Intelligent Diagnosis Technology and Equipment for Optic Nerve-Related Eye Diseases, National Engineering Research Center for Ophthalmology, Capital Medical University, Beijing, 100730, China. lishiming81@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myopia poses a growing global public health challenge, with its underlying mechanisms not yet fully understood. While insufficient daytime light exposure is a recognized protective factor, the role of nighttime light exposure remains contentious. Through a murine model, we uncover a novel melanopsin-dependent pathway by which light-at-night (LAN) exposure disrupts the expression of core circadian clock genes (including Arntl, Cry1, Per1, and Per2) and downregulates melanopsin expression in intrinsically photosensitive retinal ganglion cells (ipRGCs). These alterations are associated with axial elongation. Crucially, melanopsin-knockout mice exhibit resistance to myopic changes induced by LAN, indicating that melanopsin-dependent pathways mediate ocular growth responses. Supporting these experimental findings, our epidemiological analysis demonstrates that LAN exposure significantly increases the risk of incident myopia onset in humans. Together, these results establish a functional link between environmental light exposure and the molecular pathogenesis of myopia, identifying LAN as a modifiable risk factor for myopia. Our study provides important insights into the light-mediated myopia development and suggests melanopsin signaling as a potential target for preventive and therapeutic strategies.

Indexed as

LightMyopiaRod OpsinsSignal TransductionAnimalsCircadian RhythmHumansMelanopsinMiceMice, Inbred C57BLMice, KnockoutRetinal Ganglion CellsMelanopsinRod Opsinsaxial elongationchildren and adolescentscircadian signalinglight-at-nightmelanopsinmyopia

Identifiers

PMID41772203

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.