Evidence map›Paper›PMID 41772243›Full record

ArticleAnnals of surgical oncology2026

Risk Stratification of Fibroepithelial Breast Lesions: Clinical and Ultrasound Features Associated with Fibroadenoma and Phyllodes Tumors.

Logan Holt, Victoria Chamberlain, Tyler Shern, Michele A Gadd, Francys C Verdial, Rebecca M Kwait, Michelle C Specht, Barbara L Smith, Tolga Ozmen

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Logan HoltBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Victoria Chamberlain *Breast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Tyler Shern *Breast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Michele A GaddBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Francys C VerdialBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Rebecca M KwaitBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Michelle C SpechtBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Barbara L SmithBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA.
Tolga OzmenBreast Section, Division of Gastrointestinal and Oncologic Surgery, Massachusetts General Hospital, MGH Center for Breast Cancer, Boston, MA, USA. tozmen@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7136-6195

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFibroepithelial lesions (FELs) diagnosed on core needle biopsy frequently prompt surgical excision because of the diagnostic uncertainty between fibroadenomas (FAs) and phyllodes tumors (PTs). We sought to identify clinical and ultrasound features associated with FEL subtypes to inform individualized surgical decision-making.

methodsWe performed a retrospective review of women diagnosed with FELs on core biopsy between 2003 and 2024 who underwent diagnostic ultrasound and surgical excision. Clinical and sonographic features were compared between (1) FAs and PTs and (2) benign versus borderline/malignant PTs. Predictors were assessed using univariate and multivariable logistic regression.

resultsAmong 694 FELs in 673 women, 405 (58.4%) were FAs and 289 (41.6%) were PTs. PTs occurred in older patients (median 40 vs. 32 years), with larger tumors (2.4 vs. 1.9 cm) and higher body mass index (BMI; 25.8 vs. 23.5 kg/m DISCUSSION: Younger, premenopausal patients with normal-range BMI and small, circumscribed tumors demonstrate features strongly associated with fibroadenomas, whereas increasing size, BMI, and postmenopausal status identify higher-risk PTs. These findings support integrating clinical risk stratification into shared decision-making for the management of indeterminate FELs.

Indexed as

Breast NeoplasmsFibroadenomaPhyllodes TumorUltrasonography, MammaryAdultBiopsy, Large-Core NeedleFemaleFollow-Up StudiesHumansMiddle AgedPrognosisRetrospective StudiesRisk AssessmentYoung AdultBreast ultrasoundFibroadenomasFibroepithelial lesionsPhyllodes tumorsRisk stratificationSurgical decision-making

Identifiers

PMID41772243

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.