Evidence map›Paper›PMID 41772375›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers.

Emilie Foyard, Tao Blanchard, Brigitte Landeau, Léa Chauveau, Mikaël Naveau, Géraldine Poisnel, Eric Bui, Gaël Chetelat, Robin de Flores, Medit‐Ageing Research Group

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02977819 (Interventional Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training and Foreign Language Learning on Behavioral, Biological and Neuroimaging Measures), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02977819 nacompletednot on this map

Interventional Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training and Foreign Language Learning on Behavioral, Biological and Neuroimaging Measures

TypeinterventionalSponsorInstitut National de la Santé Et de la Recherche Médicale, FranceRan2016 to 2023Enrolled137ConditionsCognitive AgingArmsMeditation practice, Learning English as a foreign language
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emilie FoyardNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Tao BlanchardNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Brigitte LandeauNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Léa ChauveauNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Mikaël NaveauUAR3408 - US50 Cyceron, Caen Normandie University, CNRS, INSERM, CEA, GIP Cyceron, Caen, France.
Géraldine PoisnelNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Eric BuiNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Gaël ChetelatNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Robin de FloresNormandie University, UNICAEN, INSERM, UA20, NEUROPRESAGE, Cyceron, Caen, France.
Medit‐Ageing Research Group

Funding

European Union's Horizon 2020 Research and Innovation Program 667696Fondation d'Entreprise MMA des Entrepreneurs du FuturFondation recherche Alzheimer,France Life Imaging network ANR-11-INBS-0006Institut National de la Santé et de la Recherche MédicaleRégion NormandieRégion Normandie (Label d'Excellence)
6 · The paper itself

Abstract

introductionThe locus coeruleus (LC), the first region to contain tau pathology in Alzheimer's disease (AD), releases norepinephrine, which has a neuroprotective role. We examined whether LC integrity relates to whole-brain integrity and how AD biomarkers may moderate this relationship.

methodsLC intensity and volume were estimated using automatic segmentation on neuromelanin-sensitive magnetic resonance imaging acquired in n = 71 cognitively unimpaired elderly from the Age-Well randomized controlled trial. We investigated the associations between LC integrity and whole-brain gray matter volume (GMV) and glucose metabolism, as well as the interactions with amyloid positron emission tomography and plasma phosphorylated tau231, neurofilament light chain and glial fibrillary acidic protein.

resultsWhile only LC intensity was directly associated with GMV, both LC measures (intensity and volume) interacted positively with AD biomarkers to predict GMV and glucose metabolism. DISCUSSION: Our results support concomitant LC and gray matter alterations in the context of aging and elevated AD biomarker levels. CLINICAL

trial registrationAge-Well randomized clinical trial of the Medit-Ageing European Project. TRIAL REGISTRATION NUMBER: EudraCT:2016-002,441-36; IDRCB:2016-A01767-44; ClinicalTrials.gov Identifier: NCT02977819.

Indexed as

Alzheimer DiseaseLocus CoeruleusAgedAged, 80 and overAtrophyBiomarkersFemaleGlucoseGray MatterHumansMagnetic Resonance ImagingMalePositron-Emission Tomographytau ProteinsBiomarkersGlucosetau ProteinsagingAlzheimer's diseaseamyloid positron emission tomographyastrocytesaxonal integrityglucose metabolismlocus coeruleusmagnetic resonance imagingneuromelaninplasma biomarkerstau

Identifiers

PMID41772375
PMCPMC12953054

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.