Evidence map›Paper›PMID 41772647›Full record

ArticleClinical epigenetics2026

E2F1-mediated 53BP2 lactylation stabilizes p53 to induce cochlear hair cell apoptosis in mouse age-related hearing loss.

Xiaoqin Luo, Jun Liu, Chanyuan Zhang, Wei Yuan, Gang Qin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaoqin LuoDepartment of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China.
Jun LiuDepartment of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China.
Chanyuan ZhangDepartment of Otolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, 264000, China.
Wei YuanDepartment of Otolaryngology Head and Neck Surgery, Chongqing General Hospital, Chongqing, 400014, China.
Gang QinDepartment of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Sichuan, 646000, China. Qingang636@swmu.edu.cn.

Funding

The Postdoctoral Project of the Affiliated Hospital of Southwest Medical University 24001
6 · The paper itself

Abstract

Age-related hearing loss (ARHL) is a prevalent sensory deficit characterized by cochlear hair cell apoptosis, yet the underlying epigenetic mechanisms remain unclear. This study investigated the role of E2F1-mediated 53BP2 lactylation in ARHL pathogenesis using naturally aging C57BL/6J mice and HEI-OC1 cochlear hair cell-like cells. We found that E2F1 was significantly upregulated in aged cochleae, correlating with elevated ABR thresholds, hair cell loss, and apoptotic marker expression. In vitro, E2F1 overexpression promoted HEI-OC1 cell apoptosis by stabilizing p53, while E2F1 knockdown attenuated p53 accumulation and cell death under oxidative stress. Mechanistically, mass spectrometry identified 53BP2 lactylation at lysine 476 (K476), which was enhanced by E2F1. The K476R mutation abolished 53BP2-p53 binding, reduced p53 stability, and inhibited apoptosis. Further, E2F1 transcriptionally upregulated p300, a lactyltransferase that directly mediates 53BP2 K476 lactylation. p300 knockdown reversed E2F1-induced 53BP2 lactylation and p53-dependent apoptosis. These findings reveal a novel E2F1-p300-53BP2 lactylation-p53 signaling axis driving cochlear hair cell apoptosis in ARHL, highlighting potential therapeutic targets for age-related hearing loss.

Indexed as

E2F1 Transcription FactorHair Cells, AuditoryPresbycusisTumor Suppressor Protein p53AgingAnimalsApoptosisDisease Models, AnimalHumansMiceMice, Inbred C57BLE2f1 protein, mouseE2F1 Transcription FactorTrp53 protein, mouseTumor Suppressor Protein p5353BP2 lactylationAge-related hearing lossCochlear hair cell apoptosisE2F1p53

Identifiers

PMID41772647
PMCPMC13202758

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.