Evidence map›Paper›PMID 41773015›Full record

ArticleNucleic acids research2026

DAXX governs the silencing of LINE1 during spermatogenesis in mice.

Zejia Li, Chaoyang Xiong, Jin Shen, Chen Tan, Dupeng Ma, Jun Chen, Rong Liu, Qi Sun, Weihao Gong, Wenming Yuan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zejia LiState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Chaoyang XiongNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Beijing Ditan Hospital, Capital Medical University; Beijing Key Laboratory of Viral Infectious Diseases; Beijing Institute of Infectious Diseases, Beijing 100015, China.
Jin ShenState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Chen TanNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Xiangya Basic Medical Sciences, Central South University, Changsha 410083, Hunan Province, China.
Dupeng MaState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Jun ChenNew Cornerstone Science Laboratory, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, Hubei Province, China.
Rong LiuState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.ORCID 0000-0003-2561-348X
Qi SunState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Weihao GongState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Wenming YuanState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Mengya HuangState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.
Li HuangState Key Laboratory of Epigenetic Regulation and Intervention, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Yueqiu TanNHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Xiangya Basic Medical Sciences, Central South University, Changsha 410083, Hunan Province, China.ORCID 0000-0002-8359-4654
Guohong LiNew Cornerstone Science Laboratory, State Key Laboratory of Metabolism and Regulation in Complex Organisms, Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, Hubei Province, China.
Mengcheng LuoState Key Laboratory of Metabolism and Regulation in Complex Organisms, Hubei Provincial Key Laboratory of Developmentally Originated Disease, TaiKang Center for Life and Medical Sciences, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan 430071, Hubei Province, China.ORCID 0000-0001-7058-5911

Funding

Chinese Academy of Sciences JZHKYPT-2021-05Ministry of Science and Technology 2023YFA0913400National Natural Science Foundation of China 31991161National Natural Science Foundation of China 32230020National Natural Science Foundation of China 32270905Natural Science Foundation of Hubei Province 2024AFA018New Cornerstone Science FoundationShenzhen Municipal Science and Technology Innovation Committee JCYJ20240813111406009Shenzhen Municipal Science and Technology Innovation Committee JCYJ20250604122535007Wuhan UniversityYichun Maternal and Child Health HospitalZhongnan Hospital of Wuhan University ZNLH202206
6 · The paper itself

Abstract

The suppression of transposable elements in the germline is critical for safeguarding fertility. Here we identified that DAXX (death-associated protein 6), a potent transcription repressor and an H3.3 chaperone, was indispensable for silencing of transposable elements during spermatogenesis. Daxx germline conditional knockout mice exhibited delayed meiotic progression, spermiogenesis defects, and an age-dependent decline in fertility. The ablation of DAXX led to activation of evolutionarily young long interspersed nuclear element-1 (LINE1) and endogenous retrovirus (ERV) subfamilies. Further mechanistic study revealed that DAXX participated in the repression of young LINE1s by regulating H3K9me3 enrichment and maintaining DNA methylation. In summary, this study identifies DAXX as a previously unknown regulator of spermatogenesis and demonstrates that it functions as an epigenetic regulator to silence young LINE1s.

Indexed as

Adaptor Proteins, Signal TransducingCo-Repressor ProteinsGene SilencingLong Interspersed Nucleotide ElementsNuclear ProteinsSpermatogenesisAnimalsDNA MethylationEndogenous RetrovirusesHistonesMaleMeiosisMiceMice, KnockoutMolecular ChaperonesAdaptor Proteins, Signal TransducingCo-Repressor ProteinsDaxx protein, mouseHistonesMolecular ChaperonesNuclear Proteins

Identifiers

PMID41773015
PMCPMC12956357

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.