ArticleEpilepsy currents2026
Translational Research Symposium: Current State of SUDEP Research.
Article in Epilepsy currents, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
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Abstract
People with epilepsy are at 24-fold increased risk of sudden death compared to the general population. Sudden unexpected death in epilepsy (SUDEP) is defined as the sudden, unexpected, nontraumatic, and nondrowning death of an individual with epilepsy, with or without evidence of a seizure, in which postmortem examination does not reveal a structural or toxicologic cause of death. SUDEP is the leading cause of mortality in epilepsy. The SUDEP rate in general epilepsy is >1:1000 person-years, with rates in some drug-resistant epilepsies and developmental and epileptic encephalopathies exceeding 9:1000 person-years. This review summarizes the current state of the field of SUDEP research, including human cohort studies, genetic risk factors, the use of animal models of epilepsy and SUDEP, cardio-respiratory risk factors, EEG biomarkers during sleep, and the use of wearable devices to reduce SUDEP risk. Understanding of the current state of SUDEP research can help inform clinical care, motivate future research directions, and ultimately reduce the risk of SUDEP in the epilepsy population.
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