ArticleDrug design, development and therapy2026
Association Between Perioperative Dexmedetomidine Exposure and Post-Transplant Renal Outcomes: A Retrospective Analysis.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Association of low vitamin B12 status with incident dementia and stroke: an EHR database study.Frontiers in nutrition · 2026Article
- Low vitamin D status and 10-year dementia risk in sensory-impaired adults: a propensity score-matched cohort study.Frontiers in nutrition · 2026Article
- Elevated baseline vitamin B12 level and all-cause mortality risk in patients with sepsis: a cohort analysis.Frontiers in nutrition · 2026Article
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Authors and funding
7 authors.
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Abstract
Purpose: Delayed graft function remains a significant complication of kidney transplantation and affects outcomes and healthcare costs. This investigation examined the associations between perioperative dexmedetomidine exposure and postoperative outcomes in kidney transplant recipients. Methods: This retrospective cohort study analyzed data from the TriNetX Research Network of patients who underwent kidney transplantation between January 2014 and December 2024. Adult recipients were stratified according to intraoperative dexmedetomidine exposure. The primary outcome was delayed graft function within seven days post-transplantation. Secondary outcomes included acute rejection, graft failure, infection, mortality, and an estimated glomerular filtration rate (eGFR)<45 mL/min/1.73 m Results: Following propensity score matching, 3,366 patients were included in each cohort. Dexmedetomidine exposure was associated with a lower incidence of delayed graft function at seven days (22.0% versus 24.7%; odds ratio [OR] 0.86, 95% confidence interval [CI] 0.77-0.96, p=0.009). More pronounced associations emerged for acute rejection (1.2% vs 3.5%; OR 0.34, 95% CI 0.24-0.48, p<0.001) and graft failure (1.6% vs 3.8%; OR 0.42, 95% CI 0.30-0.57, p<0.001). These associations persisted through 30 days postoperatively but attenuated progressively thereafter. No significant differences were observed in transplant infection, mortality, or eGFR <45 mL/min/1.73 m Conclusion: Intraoperative dexmedetomidine exposure was associated with reduced early complications following kidney transplantation. The observational design necessitates cautious interpretation, and randomized controlled trials are required to establish causality.
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