Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
25 authors.
Laura Bub *Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0009-0002-8324-5494
Elza Evren *Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-5656-4417
Stijn Verwaerde *Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research , Ghent, Belgium.ORCID 0000-0002-1398-8746
Cecilia Ruscitti *Laboratory of Immunophysiology, GIGA Institute, University of Liège , Liège, Belgium.ORCID 0000-0002-3131-8623
Domien Vanneste *Laboratory of Immunophysiology, GIGA Institute, University of Liège , Liège, Belgium.ORCID 0000-0003-0148-8397
Pia GhoshDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0009-0007-0347-3646
Yu GaoDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-4615-3614
Natalie SleiersDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-9378-8145
Rong DengDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0787-9375
Marta López MontesDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0009-0005-8627-2238
Kelsey HowleyDepartment of Pathology, Immunology, and Microbial Pathogenesis Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0009-0000-1877-9823
Raphaël La RoccaLaboratory of Immunophysiology, GIGA Institute, University of Liège , Liège, Belgium.ORCID 0000-0003-3388-3041
Annika NiehrsDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-2190-4346
Vassilis GlarosDivision of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-6211-9515
Maria Reina-CamposDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0003-2417-5289
Barbro DahlenDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-3803-9034
Anna Smed-SörensenDivision of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-6966-7039
Harald LundDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8046-0805
Taras KreslavskyDivision of Immunology and Respiratory Medicine, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-6672-1914
Niklas K BjörkströmDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0967-076X
Andrea ReboldiDepartment of Pathology, Immunology, and Microbial Pathogenesis Program, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0003-1137-6292
Apostolos BossiosDepartment of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-0494-2690
Thomas Marichal *Laboratory of Immunophysiology, GIGA Institute, University of Liège , Liège, Belgium.ORCID 0000-0003-1688-6291
Bart N Lambrecht *Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research , Ghent, Belgium.ORCID 0000-0003-4376-6834
Tim Willinger *Department of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-8720-7199
Funding
Baillet Latour FundBurroughs-WellcomeCenter for Innovative Medicine 20190152European Research Council 101124390European Research Council 948692FEDERFonds Wetenschappelijk Onderzoek G063123NFRFS-Welbio WELBIO-CR-2022A-10Fund for Scientific Research - FNRS PDR-INTER T.0200.25Karolinska Institutet 2020-01438Karolinska Institutet 2021-00327Karolinska Institutet 2024-02407Karolinska Institutet 2-1060/2018Karolinska Institutet 2-977/2025NIH HHS AI155727Swedish Heart-Lung Foundation 20190198Swedish Heart-Lung Foundation 2020619Swedish Heart-Lung Foundation 20210434Swedish Heart-Lung Foundation 20220361Swedish Heart-Lung Foundation 20220478Swedish Heart-Lung Foundation 20240579Swedish Research Council 2019-01099Swedish Research Council 2022-01310
6 · The paper itself
Abstract
Monocytes populate tissues when local niches are depleted of tissue-resident macrophages, yet the tissue-derived signals controlling monocyte-to-macrophage differentiation are largely undefined. Here, we discovered that the oxysterol receptor GPR183 positions monocytes to sense niche signals that induce lung macrophage differentiation. We found that interstitial macrophages that continuously turn over express the oxysterol receptor GPR183, whereas alveolar macrophages that derive from embryonic progenitors and slowly turn over did not. Models of conditional tissue-resident macrophage depletion showed that newcomer monocyte-derived macrophages expressed GPR183 along their differentiation trajectory. Recruited GPR183+ monocytes interacted with fibroblasts and lack of GPR183 caused defective lung macrophage differentiation. Single-cell RNA analysis over time identified lung fibroblasts as the source of the GPR183 ligand 7α,25-dihydroxycholesterol in the empty niche. Our findings identify oxysterols as instructive signals for tissue-resident macrophage development from monocytes.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Sensing of metabolic signals via GPR183 promotes occupation of lung macrophage niches by monocytes. · full record | Socratic