ArticleGeroScience2026
Age-related increase of NLRC4 inflammasome and TGF-β1 signaling exacerbates airway inflammation and remodeling in asthma.
Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
Abstract
The prevalence and severity of asthma increase significantly with age; however, the fundamental processes are still not well understood. This study investigated the interplay between aging and asthma, specifically focusing on two critical pathways: activating NLR Family CARD domain containing 4 (NLRC4) inflammasome and transforming growth factor (TGF)-β1 signaling. Using age-specific mouse models (at 3, 13, and 23 months) and hydrogen peroxide-induced senescent human bronchial epithelial cells, we demonstrated that aging significantly exacerbated both asthmatic inflammation and airway remodeling processes. Our analysis revealed age-dependent increases in inflammatory responses, particularly emphasizing enhanced eosinophil infiltration and elevated production of T-helper type 2 cytokines. Notably, the concurrent enhancement of both NLRC4 inflammasome activation and TGF-β1-mediated signaling in aged asthmatic mice and senescent cells. Elevation of these pathways manifests as heightened airway inflammation and substantial tissue remodeling, characterized by increased collagen deposition and enhanced expression of various fibrosis-related proteins. The increased NLRC4 inflammasome and TGF-β1 signaling are implied to be key factors contributing to the increased severity of asthma observed in elderly patients. This study suggests potential therapeutic approaches specifically targeted at managing asthma in the aging population by evaluating age-related molecular mechanisms of asthma pathogenesis.
Indexed as
Identifiers
41774086What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.