Evidence map›Paper›PMID 41774233›Full record

ArticleMolecular biology reports2026

Protective effect of alpha-tocopherol succinate on Al₂O₃-NPs induced damage in NMRI mice Sertoli cells: the role of inhibin B and Connexin 43.

Milad Dadgar Naki, Elaheh Amini, Fatemeh Rohollah

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Milad Dadgar NakiDepartment of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Elaheh AminiDepartment of Animal Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran. elaheh.amini@khu.ac.ir.
Fatemeh RohollahDepartment of Cellular and Molecular Biology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSertoli cells are essential for spermatogenesis, controlling the microenvironment and interacting with germ cells. This study evaluates the preventive effect of alpha-tocopherol succinate against Al₂O₃-NPs-induced damage in NMRI mice Sertoli cells.

methodsThe effects of Al₂O₃-NPs and vitamin E were assessed on Sertoli cells using viability assays, oxidative stress markers, apoptosis detection, and gene expression analysis.

resultsAl₂O₃-NPs significantly reduced Sertoli cell viability and increased apoptosis, while vitamin E treatment mitigated these effects. Expression of INHBB and Cx43 was significantly downregulated by Al₂O₃-NPs and upregulated with vitamin E.

conclusionVitamin E alleviates Al₂O₃-NPs-induced Sertoli cell damage by reducing oxidative stress, inhibiting apoptosis, and restoring INHBB and Cx43 expression.

Indexed as

alpha-TocopherolAluminum OxideConnexin 43InhibinsSertoli CellsAnimalsAntioxidantsApoptosisCell SurvivalMaleMiceOxidative StressSpermatogenesisVitamin Ealpha-TocopherolAluminum OxideAntioxidantsConnexin 43inhibin BInhibinsVitamin Ealpha-tocopherol succinateAlumina nanoparticlesApoptosisConnexin 43inhibin BSertoli cells

Identifiers

PMID41774233

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.