Evidence map›Paper›PMID 41774790›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation.

Zhenzhou Qi, Duy Phuoc Tran, Andrejs Tučs, Roopan Thiara, Louis-Philippe Picard, Koji Tsuda, Aditya Pandey, Adnan Sljoka, Akio Kitao, Robert Scott Prosser

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenzhou Qi *Department of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Duy Phuoc Tran *School of Life Science and Technology, Institute of Science Tokyo, Tokyo 152-8550, Japan.ORCID 0000-0001-8212-3706
Andrejs Tučs *RIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.
Roopan ThiaraDepartment of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Louis-Philippe PicardDepartment of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Koji TsudaRIKEN Center for Advanced Intelligence Project, Tokyo 103-0027, Japan.ORCID 0000-0002-4288-1606
Aditya PandeyDepartment of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.ORCID 0000-0002-7549-985X
Adnan SljokaDepartment of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.
Akio KitaoSchool of Life Science and Technology, Institute of Science Tokyo, Tokyo 152-8550, Japan.ORCID 0000-0002-5221-0806
Robert Scott ProsserDepartment of Chemistry, University of Toronto, Chemical and Physical Sciences, University of Toronto at Mississauga, Mississauga, ON L5L 1C6, Canada.ORCID 0000-0001-9351-178X

Funding

Canadian Institutes of Health Research (CIHR) MOP-43998Japan Agency for Medical Research and Development (AMED) 25wm0325075MEXT | Japan Society for the Promotion of Science (JSPS) JP23H02424MEXT | Japan Society for the Promotion of Science (JSPS) JP23H02445MEXT | Japan Society for the Promotion of Science (JSPS) JP23H04058MEXT | Japan Society for the Promotion of Science (JSPS) JP23K14154MEXT | Japan Society for the Promotion of Science (JSPS) JP24H01357MEXT | Japan Society for the Promotion of Science (JSPS) JP24H02259
6 · The paper itself

Abstract

The human adenosine A

Indexed as

Receptor, Adenosine A2AReceptors, G-Protein-CoupledSodiumTryptophanAllosteric RegulationAllosteric SiteBinding SitesHumansLigandsProtein BindingProtein ConformationADORA2A protein, humanLigandsReceptor, Adenosine A2AReceptors, G-Protein-CoupledSodiumTryptophan19F NMRadenosine A2AallosteryGPCRs

Identifiers

PMID41774790
PMCPMC12974507

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.