Evidence map›Paper›PMID 41775841›Full record

ArticleNature chemistry2026

Collective synthesis of 1,2,4-trisubstituted, meta- and ortho-substituted arene bioisosteres from bicyclobutanes.

Feng Wu, Ji-Jie Wang, Yuanjiu Xiao, Quanxin Peng, Yu-Jie Li, Keren Peng, Qianlan Han, Mengran Wei, Yu Qian, Wei Zhang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Feng Wu *State Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Ji-Jie Wang *State Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Yuanjiu Xiao *State Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Quanxin PengState Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Yu-Jie LiState Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China.
Keren PengState Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China.
Qianlan HanSchool of Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China.
Mengran WeiKey Laboratory of Mesoscopic Chemistry of Ministry of Education, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China.
Yu QianState Key Laboratory of Anti-Infective Drug Discovery and Development, Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, People's Republic of China. qianyu5@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0001-9742-3330
Wei ZhangSchool of Medicine, Nanjing University of Chinese Medicine, Nanjing, People's Republic of China. zhangwei@njucm.edu.cn.ORCID http://orcid.org/0000-0003-1928-5758
Guoqiang WangKey Laboratory of Mesoscopic Chemistry of Ministry of Education, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, People's Republic of China. wangguoqiang710@nju.edu.cn.ORCID http://orcid.org/0000-0001-9666-1919
Jian-Jun FengState Key Laboratory of Chemo and Biosensing, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, People's Republic of China. jianjunfeng@hnu.edu.cn.ORCID http://orcid.org/0000-0002-6094-3268

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22471068National Natural Science Foundation of China (National Science Foundation of China) 82371812
6 · The paper itself

Abstract

Replacing benzene rings with C(sp

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.