Evidence map›Paper›PMID 41775928›Full record

ReviewPsychopharmacology2026

Beyond dopamine: Broader neuromodulatory contributions in sign- and goal-tracking.

Amber Datta, Arya Datta, Noah Collins, Stephanie L Grella, Ali Gheidi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amber DattaLincoln Memorial University-DeBusk College of Osteopathic Medicine, 6965 Cumberland Gap Pkwy, Harrogate, TN, USA.
Arya DattaMercer University School of Medicine, Macon, GA, USA.
Noah CollinsMercer University School of Medicine, Macon, GA, USA.
Stephanie L GrellaDepartment of Psychology, Program In Neuroscience, Loyola University Chicago, 1032 W Sheridan Rd, Chicago, IL, USA.
Ali GheidiMercer University School of Medicine, Macon, GA, USA. Gheidi_a@mercer.edu.

Funding

Norepinephrine modulates medial prefrontal cortex neural ensembles that control cocaine seeking behaviorK01DA055068 · NIDA · WAYNE STATE UNIVERSITY · PI Ali Gheidi · 2022 to 2026
$814k
NIDA NIH HHS K01 DA055068NIH HHS 5K01DA055068
6 · The paper itself

Abstract

Sign- and goal-tracking behaviors provide a powerful framework for understanding individual differences in cue-motivated responding and vulnerability to addiction. While dopamine has long been recognized as central to the attribution of incentive salience, growing evidence indicates that multiple neuromodulatory systems contribute to these behaviors through distinct mechanisms. This review synthesizes findings on the cholinergic, serotonergic, adrenergic, opioid, and stimulant (nicotine, caffeine) systems in modulating sign- and goal-tracking in rodents. A better understanding of these mechanisms may guide individualized interventions to reduce cue-triggered relapse and improve addiction treatment outcomes.

Indexed as

AddictionGoal trackingIndividual differencesSign tracking

Identifiers

PMID41775928
PMCPMC13141539

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.