Evidence map›Paper›PMID 41775935›Full record

ArticleNature2026

Genetically encoded assembly recorder temporally resolves cellular history.

Yuqing Yan, Jiaxi Lu, Zhe Li, Zuohan Zhao, Timothy F Shay, Shunzhi Wang, Yaping Lei, Yimei Wang, Wei Chen, Patrick Parker and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Chemical reviews · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Yuqing Yan *Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0008-1956-4689
Jiaxi Lu *Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Zhe Li *Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9402-4940
Zuohan ZhaoDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1812-6237
Timothy F ShayDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.ORCID http://orcid.org/0000-0001-6591-3271
Shunzhi WangInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5033-7478
Yaping LeiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Yimei WangDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Wei ChenSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Patrick ParkerSolomon H. Snyder Department of Neuroscience, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Hongru YangDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Aileen QiDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yongzhi SunDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5267-6780
Dwight E BerglesKavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7133-7378
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7896-6217
Dingchang LinDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. dclin@jhu.edu.ORCID http://orcid.org/0000-0002-9354-5952

Funding

Protein assemblies as genetically encoded mechanical actuators for intracellular mechanobiology researchR35GM147274 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Dingchang Lin · 2022 to 2026
$2.0M
Curved Implantation of Flexible Microelectrode Arrays for High-Density Mapping of Nonlinear Brain Structures and CircuitsR21EY035955 · NEI · JOHNS HOPKINS UNIVERSITY · PI Dingchang Lin · 2024 to 2026
$631k
NEI NIH HHS R21 EY035955NIGMS NIH HHS R35 GM147274
6 · The paper itself

Abstract

Cells constantly change their molecular state in response to internal and external cues

Indexed as

CellsSpatio-Temporal AnalysisAnimalsBrainCell LineageFemaleHumansInflammationMaleMiceNeuronsNF-kappa BSignal TransductionTime FactorsTranscription, GeneticNF-kappa B

Identifiers

PMID41775935
PMCPMC13102709

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.