ArticleNpj biological timing and sleep2025
CHRONO regulates the circadian clock via the REV-ERBα - BMAL1 loop.
Article in Npj biological timing and sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Dihydroergotamine alleviates circadian rhythm disorders through predicted interaction with to CRY1.Molecular diversity · 2026Article
- c-MYC is Transcribed in a Circadian Manner and Acts a Clock Disruptor whose Timing Minimizes its Impacts.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The period length of the circadian clock is important for organisms to maintain homeostasis. CHRONO has been shown to play an important role in regulating the period of the mammalian clock and has recently been implicated to function in several important physiological aspects. However, the mechanisms underlying transcriptional regulation by CHRONO to determine the circadian period remain elusive. Here, we report that CHRONO acts as a transcriptional repressor on JUN/FOS complexes independent of the classical BMAL1/CLOCK complexes. CHRONO can regulate BMAL1 expression by differentially regulating REV-ERBα and REV-ERBβ. We further developed a mathematical model and the model simulations strongly agreed with our findings that CHRONO acts on both REV-ERBα and BMAL1 to regulate the circadian period. The model also sheds light on the physiological significance of the fact that CHRONO cycles in most of the mammalian tissues. Thus, our experimental and computational approaches reveal the molecular mechanisms of regulating the circadian period by an important circadian component, CHRONO.
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Registered trials
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