Evidence map›Paper›PMID 41776167›Full record

ArticleTranslational psychiatry2026

ATP bioenergetics and fatigue in young adults with and without major depression.

Kathryn R Cullen, Susannah J Tye, Bonnie Klimes-Dougan, Hannes M Wiesner, Roger B Varela, Brooke Morath, Lin Zhang, Wei Chen, Xiao-Hong Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Female chronic social defeat stress (Frontiers in systems biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Minnesota, Minneapolis, MN, USA. rega0026@umn.edu.ORCID http://orcid.org/0000-0001-9631-3770
Susannah J TyeQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1291-4304
Bonnie Klimes-DouganDepartment of Psychology, College of Liberal Arts, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-2107-0038
Hannes M WiesnerCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-3046-4933
Roger B VarelaQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.
Brooke MorathDepartment of Psychiatry and Psychology, Mayo Clinic - Rochester, Rochester, MN, USA.
Lin ZhangDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Wei ChenCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Xiao-Hong ZhuCenter for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

Funding

Breaking Spatiotemporal Barriers of MR Imaging Technologies to Study Human Brain Function and NeuroenergeticsU01EB026978 · NIBIB · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, ZHU, XIAO-HONG · 2018 to 2022
$6.4M
Establishing translational neuroimaging tools for quantitative assessment of energy metabolism and metabolic reprogramming in healthy and diseased human brain at 7TR01NS133006 · NINDS · UNIVERSITY OF MINNESOTA · PI Wei Chen, XIAO-HONG ZHU · 2023 to 2026
$2.5M
NIBIB NIH HHS U01 EB026978U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS133006
6 · The paper itself

Abstract

Fatigue is a pervasive and difficult-to-treat symptom of major depressive disorder (MDD) that contributes to disability. Understanding this problem in its earlier stages will be critical for averting long-term negative outcomes. To investigate the molecular roots of fatigue in early-stage depression, the current work measured bioenergetic mechanisms, with a focus on adenosine triphosphate (ATP), in brain and blood cells in young adults with MDD versus healthy controls (HC). To measure ATP concentration and ATP production rate in the visual cortex, we utilized

Indexed as

Adenosine TriphosphateEnergy MetabolismFatigueMajor Depressive DisorderVisual CortexAdultCase-Control StudiesFemaleHumansLeukocytes, MononuclearMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleYoung AdultAdenosine Triphosphate

Identifiers

PMID41776167
PMCPMC13004833

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.