Ultrasound-assisted aqueous two-phase extraction of flavonoids from erigeron breviscapus: process optimization, structural characterization, antioxidant study, and DFT calculation.

Huiqin Qian, Menglin Wang, Haibo Xu, Kun Feng, Yaxuan Li, Yingfan Hu, Yanling Li

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Huiqin QianNorth Henan Medical University, Xinxiang, 453000, China.

Menglin WangNorth Henan Medical University, Xinxiang, 453000, China.

Haibo XuNorth Henan Medical University, Xinxiang, 453000, China.

Kun FengNorth Henan Medical University, Xinxiang, 453000, China.

Yaxuan LiNorth Henan Medical University, Xinxiang, 453000, China.

Yingfan HuNorth Henan Medical University, Xinxiang, 453000, China.

Yanling LiNorth Henan Medical University, Xinxiang, 453000, China. 17522009@nhmu.edu.cn.

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6 · The paper itself

Abstract

The well-known medicinal plant Erigeron breviscapus has long been used to treat cerebral embolism, cerebral thrombosis, and cerebral hemorrhage. Response surface methodology (RSM) was applied to optimize the ultrasonic-assisted extraction process of total flavonoids from Erigeron breviscapus (EBTF) using aqueous two-phase system. The flavonoids from E. breviscapus were qualitatively identified using UPLC-Q-TOF-MS/MS. The capacity of EBTF to scavenge ·OH was used to assess its antioxidant activity. To determine the active sites in the primary bioactive components that scavenge ·OH, density functional theory (DFT) calculations were conducted. Total flavonoid content (TFC) from E. breviscapus was 48.53 mg/g under ideal conditions with PEG2000 mass fraction of 16%, (NH

Indexed as

AntioxidantsErigeronFlavonoidsPlant ExtractsChromatography, High Pressure LiquidDensity Functional TheoryTandem Mass SpectrometryAntioxidantsFlavonoidsPlant ExtractsDensity functional theoryErigeron breviscapusFlavonoidsResponse surface methodologyUltrasonic

Identifiers

PMID41776200

DOI10.1038/s41598-026-41556-6

PMCPMC13066486

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