Evidence map›Paper›PMID 41776263›Full record

ArticleNPJ cardiovascular health2024

Pre-exposure immunohematologic features of heart failure associate with COVID-19 mortality.

David A Zidar, Brigid M Wilson, Sadeer G Al-Kindi, David Sweet, Steven Juchnowski, Lauren Huntington, Carey Shive, Jürgen Bosch, Christopher King, Jonathan Karn and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ cardiovascular health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

David A ZidarCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA. Daz21@case.edu.
Brigid M WilsonLouis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH, 44106, USA.
Sadeer G Al-KindiCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
David SweetCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Steven JuchnowskiCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Lauren HuntingtonLouis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd., Cleveland, OH, 44106, USA.
Carey ShiveCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Jürgen BoschCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Christopher KingCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Jonathan KarnCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Mina K ChungHeart Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Carl B GillombardoCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Mohammad KarnibCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Varun SundaramCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Sahil A ParikhCenter for Interventional Vascular Therapy, Division of Cardiology, Columbia University Irving Medical Center, 161 Fort Washington Avenue, New York, NY, 10032, USA.
Mukesh JainDepartment of Molecular Biology, Cell Biology and Biochemistry, The Warren Alpert Medical School of Brown University, 222 Richmond St, Providence, RI, 02903, USA.
Douglas D GunzlerCenter for Healthcare Research and Policy, Case Western Reserve University at MetroHealth, 2500 MetroHealth Drive, Cleveland, OH, 44109, USA.
Jacek SkarbinskiDivision of Research, Kaiser Permanente Northern California, 275 West MacArthur Boulevard, Oakland, CA, 94611, USA.
W H Wilson TangHeart Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Donald D AnthonyCase Western Reserve University School of Medicine, 10900 Euclid Ave, Cleveland, OH, 44106, USA.
Timothy A ChanHeart Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Jarrod E DaltonHeart Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Funding

Pre-exposure Immunologic Health and Linkages to SARS-COV2 Serologic Responses, Endothelial Cell Resilience, and Cardiovascular Complications: Defining the mechanistic basis of high risk endotypes.U01CA260513 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI CHAN, TIMOTHY AN-THY, ZIDAR, DAVID A. · 2020 to 2024
$3.4M
NCI NIH HHS U01CA260513United States Veteran Administration COVID19-8900-05
6 · The paper itself

Abstract

Chronic heart failure, like diabetes, is a pro-inflammatory cardiometabolic condition, but its association with immunodeficiency is less well established. We conducted a retrospective cohort study of US Veterans infected during the first wave of COVID-19 (n = 92,533) to identify relationships between comorbidities, pre-infection immunohematologic (IH) features (based on complete blood cell count parameters), and 60-day mortality. A biomarker sub-analysis of anti-SARS CoV2 antibodies and cytokine levels was also performed (n = 44). Heart failure was independently associated with higher COVID-19 mortality and with the specific IH alterations (especially relative anemia, anisocytosis, and lymphopenia) which themselves predicted non-survival or protracted inflammation. Over half the risk conferred by heart failure was mediated by its anticipatory IH features whereas diabetes risk was unrelated to its associated IH profile. These findings indicate that heart failure is associated with a COVID-19 immunodeficiency distinct from that of diabetes which correlates with antecedent erythrocyte and lymphocyte dyshomeostasis.

Identifiers

PMID41776263
PMCPMC12912350

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.