ArticleMediators of inflammation2025
Imbalance of the Immune Response According to Alcohol Consumption Patterns.
Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Alcohol intake promotes the translocation of endotoxins, stimulating immune cell activation and the production of cellular mediators, dysregulating the inflammatory process. We simultaneously evaluated the number of immune cells and cytokine concentrations, in relation to the pattern of alcohol consumption. Methods: A cross-sectional study included five groups according to alcohol intake (hazardous drinking [HD], low alcohol use disorders [AUDs] [l-AUDs], moderate-severe AUDs [ms-AUDs], no decompensated cirrhosis, and alcohol-associated hepatitis [AH]). The control (CT) group was comprised of blood bank donors with an AUD Identification Test (AUDIT) <8 and occasional alcohol consumption of ≤10 g/day. Hematological and biochemical analyses were performed. Lymphocyte subsets (CD3 Results: A total of 780 subjects were enrolled and 427 were classified according to the alcohol consumption criteria. The ms-AUD group showed the highest levels of CD8 Conclusion: The number of immune cells (CD4
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