Evidence map›Paper›PMID 41777490›Full record

ArticleBrain communications2026

A GABAergic pathway from dorsal raphe nucleus to paraventricular thalamic nucleus modulates incision-related pain behaviour in mice.

Huijie Zhang, Lei Li, Bo Sun, Yinxiu Gao, Jingjing Zhang, Ce Bian, Yibo Wang, Man Li, Songxue Su, Weidong Zang and 1 more

Abstract read
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Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Huijie ZhangDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.ORCID https://orcid.org/0009-0004-6747-2114
Lei LiDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Bo SunDepartment of Rehabilitation Medicine, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China.
Yinxiu GaoDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Jingjing ZhangDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Ce BianDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Yibo WangDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Man LiDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Songxue SuDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.ORCID https://orcid.org/0000-0003-2671-3888
Weidong ZangDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.
Jing CaoDepartment of Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan 450001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incision pain is a prevalent condition in clinical practice, affecting approximately 50% of patients and significantly diminishing their quality of life. However, the central mechanisms underlying incision pain remain unclear. Here, we established a paw incision model that increased neuronal excitability in the paraventricular thalamic nucleus (PVT). Multiple tracing methods revealed an inhibitory ascending neural pathway from the dorsal raphe nucleus (DRN) to the PVT, with external nociceptive stimuli enhancing the activity of this pathway. Inhibition of the DRN

Indexed as

GABAA receptorsGABAergic neuronsincision painneural pathway

Identifiers

PMID41777490
PMCPMC12952966

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.