Evidence map›Paper›PMID 41777792›Full record

ArticleJournal of bone oncology2026

Doxorubicin enhances adipogenesis in an FGF2-dependent manner and induces a tumour-promoting secretory phenotype.

Lauren M Kreps, Edward Yakubovich, Huijun Zhao, Selam Yimer, Edward Yang, Juliet Cruz, Barbara Vanderhyden, Christina L Addison

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lauren M KrepsCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Edward YakubovichCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Huijun ZhaoCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Selam YimerCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Edward YangCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Juliet CruzCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Barbara VanderhydenCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.
Christina L AddisonCancer Research Program, Ottawa Hospital Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bone marrow microenvironment is highly saturated with bone marrow adipocytes (BMA), which differentiate from their precursor, mesenchymal stem cells (MSC). Evidence from patient trials suggests that bone marrow adiposity is increased in patients following some forms of chemotherapy. Moreover, it has been suggested that BMA can confer chemotherapeutic resistance to tumour cells, thereby ascribing a tumour-supportive role to BMA. We investigated the effect of chemotherapy on adipogenesis of human MSC

Indexed as

AdipogenesisBone marrow adipocyteCancerChemotherapyFibroblast growth factorMesenchymal stem cellTumour growth

Identifiers

PMID41777792
PMCPMC12950464

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.