In one paragraphArticle in International journal of medical science and dental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
27 authors.
Ayodele Obianuju OkwuosaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-3454-4324 George Uchenna ElejeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria. / Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria.ORCID 0000-0002-0390-2152 Okechukwu Christian IkpezeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Emmanuel Onyebuchi UgwuDepartment of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Ituku-Ozalla, Enugu, Nigeria.ORCID 0000-0002-3342-434X Boniface Chukwuneme OkpalaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria. / Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria.ORCID 0000-0003-1693-373X Golibe Christian IkpezeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0001-5034-9276 Ifeanyi Ogochukwu OkonkwoDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-3004-9959 Hillary Ikechukwu ObiagwuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0002-4652-3320 Odigonma Zinobia IkpezeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-2351-1076 Ifeanyichukwu Jude OforDepartment of Obstetrics and Gynaecology, ESUT Teaching Hospital, Enugu, Nigeria.ORCID 0000-0003-2276-9446 Emeka Philip IgbodikeDepartment of Obstetrics and Gynaecology, Kelina Hospital, Victoria Island, Lagos, Nigeria.ORCID 0000-0003-4698-6226 Joseph Odirichukwu UgboajaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Kingsley Emeka EkwuaziDepartment of Obstetrics and Gynaecology, College of Medicine, University of Nigeria Ituku-Ozalla, Enugu, Nigeria.ORCID 0000-0002-6213-4018 Chukwuemeka Chukwubuikem OkoroDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0001-5772-661X Chigozie Geoffrey OkaforDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-4458-8216 Onyecherelam Monday OgelleDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0002-8772-3193 Chukwunonso Isaiah EnechukwuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-4639-5127 Lazarus Ugochukwu OkaforDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.
Osita Samuel UmeononihuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0003-1636-3845 Zebulon Chiawolamoke OkechukwuDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0009-0008-4481-8820 Chukwudubem Chinagorom OnyejiakaDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0001-6471-2566 Chijioke Ogomegbunam EzeigweDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0002-6795-3063 Adanna Vivian EgwimDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0001-5015-1999 Chukwunwendu Aloysius OkekeDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria.ORCID 0000-0002-8305-2978 Johnbosco Emmanuel MamahDepartment of Obstetrics and Gynaecology, Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria.ORCID 0000-0002-9039-0238 Joseph Ifeanyichukwu IkechebeluDepartment of Obstetrics and Gynaecology, Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State, Nigeria. Effective Care Research Unit, Department of Obstetrics and Gynaecology, Nnamdi Azikiwe University, Awka, Nigeria.ORCID 0000-0003-2515-8464 Ahizechukwu Chigoziem EkeDivision of Maternal Fetal Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0070-9840 Funding
Understanding Medication Adherence Benchmarks, Safety and Pharmacometrics of Novel Antiretrovirals in Pregnant Women Living with HIV.K23HD104517 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EKE, AHIZECHUKWU C. · 2020 to 2024
$857kNICHD NIH HHS K23 HD104517
6 · The paper itselfAbstract
Background: A significant gap exists in understanding the efficacy and safety of oral immediate-release nifedipine and intravenous hydralazine in the control of severe hypertension in pregnancy within the context of randomised control trials. Objectives: To compare the efficacy and safety of oral immediate-release nifedipine and intravenous hydralazine for controlling severe hypertension in pregnancy. Methods: Randomised, double-blind, 2-arm, single center non-inferiority trial in pregnant women with confirmed severe hypertension in pregnancy who were randomised in a 1:1 ratio to receive oral immediate-release Nifedipine (n=35) or intravenous hydralazine (n=35) was done from 20 Results: The baseline socio-demographic parameters were similar between the two groups. The mean durations taken to reach the target blood pressure for patients that received oral immediate-release nifedipine versus intravenous hydralazine were 48.29min±31.95 and 41.20min±26.98 respectively (P=0.320). The mean dose used before target blood pressure was reached, the proportion of participants that crossed over to another treatment allocation, and the proportion that required a rescue antihypertensive (labetalol) to achieve the target blood pressure were similar between the two groups (P >0.05). None of the participants that received oral immediate-release nifedipine had maternal or neonatal side effect while one participant (2.9%) that received intravenous hydralazine had nausea and vomiting. Conclusion: Oral immediate-release nifedipine is as effective as intravenous hydralazine in controlling severe hypertension in pregnancy. Both have remarkable materno-fetal safety profile and its non-invasive nature makes it an appealing modality especially in resource poor countries. More robust studies are encouraged to increase the evidence for its use as first line antihypertensives, especially in low and middle-income countries. Trial Registration: Pan African Clinical Trial registry, PACTR201906662822573, registration date: 19
Indexed as
Acute blood pressure controlHypertensive disorders of pregnancyIntravenous hydralazineLow- and middle-income countriesMaternal and fetal outcomesOral immediate-release nifedipineRandomised controlled trialSevere hypertension in pregnancy
Identifiers
PMID41777805
PMCPMC12951476
What Socratic holds
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