Evidence map›Paper›PMID 41777821›Full record

ArticleRSC advances2026

Rational design of click-assembled chiral dendrimers: anticancer activity and molecular dynamics study.

Tamer El Malah, Ahmed A El-Rashedy

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tamer El MalahPhotochemistry Department, Chemical Industries Research Institute, National Research Centre 33 El Buhouth Street, P.O. Box 12622 Cairo Egypt tmara_nrc3000@yahoo.com.ORCID https://orcid.org/0000-0002-2868-3857
Ahmed A El-RashedyChemistry of Natural and Microbial Products Department, National Research Centre Dokki 12622 Cairo Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study details the rational design, synthesis, and biological evaluation of a range of chiral dendritic compounds created using modular copper(i)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. We developed first-generation dendrimers (6-9) with systematically different degrees of chirality, comprising fully chiral, achiral, and mixed-chirality systems, as well as a multivalent second-generation dendrimer (12). The biological screening against human cancer cell lines (HCT-116, HepG-2, and MCF-7) revealed that the fully chiral first-generation dendrimer (9) was the most effective. Significantly, dendrimer (9) presented improved selectivity, as evidenced by a favorable therapeutic window with considerably reduced toxicity to normal WI-38 fibroblasts (IC

Identifiers

PMID41777821
PMCPMC12951598

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.