ArticleRSC advances2026
Porphyrin-based zinc metal-organic framework loaded with gallic acid as a novel nanoplatform exhibiting H
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
A zinc-based metal-organic framework (MOF) engineered from tetrakis(4-carboxyphenyl) porphyrin (TCPP) as an organic linker and functionalized with gallic acid (GA) as an active therapeutic agent demonstrates remarkable potential for cancer treatment. The resulting Zn-TCPP@GA hybrid framework exhibits a high specific surface area, extensive π-π conjugation, and superior catalytic performance, collectively facilitating efficient reactive oxygen species (ROS) generation-an essential mechanism underlying chemodynamic therapy (CDT). Incorporation of GA significantly enhances the redox activity and biocompatibility of the framework. GA actively participates in modulating the tumor environment by depleting intracellular glutathione (GSH), thereby impairing the antioxidant defense machinery of cancer cells and amplifying ROS-mediated oxidative stress. Comprehensive physicochemical characterization confirmed that Zn-TCPP@GA exhibits an intrinsic peroxidase-mimetic and ROS generation mechanism
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