Evidence map›Paper›PMID 41777883›Full record

ArticleFrontiers in immunology2026

Platelet-rich plasma-derived microRNA let-7a-5p alleviates knee osteoarthritis by regulating macrophage polarization and improving inflammatory microenvironment.

Qishan Li, Mengjie Wang, Dong Wang, Yaochi Nie, Xueyuan Sun, Lin Na, Dongmei Yan, Yuhang Ma, Hui Wang

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qishan LiDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Mengjie WangDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Dong WangScientific Research Centre, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yaochi NieDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Xueyuan SunDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Lin NaDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Dongmei YanDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Yuhang MaDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Hui WangDepartment of Blood Transfusion, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Knee osteoarthritis (KOA) is closely associated with an imbalance in macrophage M1/M2 polarization within its inflammatory microenvironment. Platelet-rich plasma (PRP) has demonstrated therapeutic efficacy in KOA. Moreover, microRNAs (miRNAs) also play a protective or destructive role in the pathogenesis of KOA. This study aims to elucidate the molecular mechanisms by which PRP-related miRNAs ameliorate the inflammatory microenvironment to alleviate KOA. Methods: An Results: Conclusion: PRP reshapes macrophage polarization by regulating the let-7a-5p/MAPK8 axis, thereby improving the inflammatory microenvironment of KOA and providing a potential new therapeutic target for KOA management.

Indexed as

Macrophage ActivationMacrophagesMicroRNAsOsteoarthritis, KneePlatelet-Rich PlasmaAnimalsCellular MicroenvironmentCytokinesDisease Models, AnimalHumansMaleRatsRats, Sprague-DawleyCytokinesMicroRNAsMIRNLET7 microRNA, ratinflammatory microenvironmentknee osteoarthritislet-7a-5pmacrophage polarizationMAPK8platelet-rich plasma

Identifiers

PMID41777883
PMCPMC12950549

What Socratic holds

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.