Evidence map›Paper›PMID 41777913›Full record

ArticleGastroenterology and hepatology from bed to bench2025

Prognostic nutritional index and systemic inflammation index as predictors of cirrhosis severity: a cross-sectional study.

Behzad Hatami, Omid Ghanbarpour, Leila Pasharavesh, Amir Hassan Rabani, Toktam Alirezaei, Zahra Geshani, Sahar Kalami, Hosein Jafary

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Article in Gastroenterology and hepatology from bed to bench, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Behzad HatamiGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Omid GhanbarpourInternal Medicine Department, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Leila PasharaveshGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amir Hassan RabaniDepartment of Transplant & Hepatobiliary Surgery, Taleghani hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Toktam AlirezaeiResearch Center of Artificial Intelligence in Health, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra GeshaniStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sahar KalamiFaculty of Medical Basic Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran.
Hosein JafaryStudent Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: We assessed whether the Prognostic Nutritional Index (PNI) and the Systemic Inflammation Index (SII) are associated with cirrhosis severity and decompensation. Background: Cirrhosis severity is routinely staged with MELD and Child-Pugh scores, which only partially capture nutritional and inflammatory status. Methods: We conducted a cross-sectional study of 202 cirrhotic adults at Shahid Beheshti University hospitals (2018-2022). Demographic, clinical, and lab data were obtained from records. PNI (10 × albumin + 0.005 × lymphocytes) and SII (platelets × neutrophils ÷ lymphocytes) were calculated. Associations with MELD, Child-Pugh, and complications were analyzed (α = 0.05; SPSS). Results: Higher SII was associated with greater disease severity, including higher MELD (P = 0.040) and higher Child-Pugh class (overall P = 0.010), with SII levels higher in Child-Pugh class C than in class B (P = 0.001). PNI showed an inverse relationship with MELD, consistent with better nutritional status at lower severity. PNI was higher in patients without ascites (P = 0.020). Both indices differed in patients with hepatic encephalopathy versus those without (P = 0.010). Moreover, SII did not differ across variceal grades (P = 0.891), whereas PNI was lower in higher grades (overall P = 0.005). Conclusion: PNI and SII exhibit significant associations with established severity measures in cirrhosis. These indices may complement MELD and Child-Pugh by integrating nutritional and inflammatory information into routine assessment. Prospective, externally validated studies are warranted to determine predictive utility and clinical impact.

Indexed as

AscitesEsophageal varicesInflammationLiver cirrhosisNutritional statusPredictive value of testsPrognosisSeverity of illness index

Identifiers

PMID41777913
PMCPMC12920691

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.