Evidence map›Paper›PMID 41778157›Full record

ArticleFrontiers in endocrinology2026

Computational screening and molecular dynamics reveal curcumin III and taxifolin as potential thyroid receptor modulators for hypothyroidism therapy.

Babatunji Emmanuel Oyinloye, Adetola Ibukunoluwa Adewale, Shalom Oluwafunke Adeyemi, Omotola Martha Fajana, Olutosin Samuel Olusola, Oluwatoyin Mary Oyinloye, Aderonke Moyosola Ayeni, Ayodeji Benjamin Akawa, Olajumoke Tolulope Idowu, Austine Idowu Ibikunle and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Babatunji Emmanuel OyinloyeInstitute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria.
Adetola Ibukunoluwa AdewaleInstitute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria.
Shalom Oluwafunke AdeyemiInstitute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria.
Omotola Martha FajanaInstitute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria.
Olutosin Samuel OlusolaInstitute for Drug Research and Development, S.E. Bogoro Center, Afe Babalola University, Ado-Ekiti, Nigeria.
Oluwatoyin Mary OyinloyeDepartment of Biological Sciences, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Aderonke Moyosola AyeniPhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Ayodeji Benjamin AkawaPhytomedicine, Biochemical Toxicology and Biotechnology Research Laboratories, Department of Biochemistry, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Olajumoke Tolulope IdowuIndustrial Chemistry Unit, Department of Chemical Sciences, College of Sciences, Afe Babalola University, Ado-Ekiti, Nigeria.
Austine Idowu IbikunleDepartment of Community Medicine, Federal Teaching Hospital (FETHI), Ido-Ekiti, Nigeria.
Folake Olayinka OlojoDepartment of Chemical Sciences, Dominion University, Ibadan, Nigeria.
Basiru Olaitan AjiboyePhytomedicine and Molecular Toxicology Research Laboratory, Department of Biochemistry, Federal University Oye-Ekiti, Oye-Ekiti, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypothyroidism is a condition marked by inadequate thyroid hormone production. It is typically treated with Levothyroxine, which, despite its effectiveness, can cause adverse effects on metabolism and the cardiovascular system. In this study, an in silico approach was used to screen phytochemicals from

Indexed as

CurcuminHypothyroidismMolecular Dynamics SimulationQuercetinReceptors, Thyroid HormoneThyroid Hormone Receptors betaHumansMolecular Docking SimulationCurcuminQuercetinReceptors, Thyroid HormonetaxifolinThyroid Hormone Receptors betacurcuma longahypothyroidismmolecular dockingmolecular dynamics simulationmoringa oleiferanigella sativaphytochemicalsthyroid receptors

Identifiers

PMID41778157
PMCPMC12950546

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.