ArticleFrontiers in endocrinology2026
Synergistic therapeutic effects of metformin and curcumin on polycystic ovary syndrome via regulation of insulin resistance and oxidative stress in a rat model.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder characterized by insulin resistance, hyperandrogenism, and elevated oxidative stress. The present study aimed to investigate the synergistic therapeutic effects of metformin and curcumin on insulin resistance and oxidative stress in a rat model of PCOS. Materials and methods: Thirty female Sprague-Dawley rats were randomly assigned to blank control (n = 6) and experimental (PCOS) groups (n = 24). The PCOS model was induced through daily subcutaneous injections of dehydroepiandrosterone (DHEA, 60 mg/kg) for 20 days. Subsequently, the experimental group was subdivided into four groups: PCOS-only, PCOS-metformin (300 mg/kg), PCOS-curcumin (50 mg/kg), and PCOS-metformin-curcumin (combined treatment). Treatments were administered daily via oral gavage for another 20 days. Estrous cycles, ovarian morphology, serum sex hormones, insulin resistance, and oxidative stress in ovarian tissues were assessed. Results: Combined treatment with metformin and curcumin significantly restored estrous cyclicity, improved ovarian morphology, reduced serum testosterone and luteinizing hormone levels, decreased LH/FSH ratio, and ameliorated insulin resistance compared to monotherapy groups. Moreover, the combined treatment markedly decreased ovarian oxidative stress markers (ROS and MDA) and enhanced antioxidant enzyme activities (GPx, SOD, GSH), surpassing the effects of either agent alone. Conclusion: Combined administration of metformin and curcumin demonstrated synergistic therapeutic effects in PCOS rats by concurrently addressing insulin resistance and oxidative stress. These findings support the clinical potential of this combination as an effective strategy for managing PCOS. Further clinical studies are necessary to validate these promising preclinical findings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.