ArticleFrontiers in endocrinology2026
Temporal trajectory of plasma miRNA during the peri-implantation stage: comparing implantation success and failure in single frozen-thawed blastocyst transfers.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Implantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful implantation. However, the trajectory differences in plasma miRNA expression between women with implantation failure and success, as well as the potential role of those miRNAs, remain unclear. Methods: This study included 84 women who underwent single frozen-thawed blastocyst transfer in a natural cycle. For each patient, longitudinal plasma samples across five time points throughout the peri-implantation period (day0/D3/D5/D7/D9) were collected and underwent miRNA sequencing. The failure group ( Results: Twenty-four DDE miRNAs (FDR < 0.05) exhibited five temporal patterns: recession (R), growth (G), D3-trough (T), multimodal (M), and D5-trough (T2). The success group predominantly showed M-pattern miRNAs (62.5%), while failures demonstrated pattern transitions (M → T/T2) and exclusive T-pattern expression. Clinical relevance revealed eight DDE miRNAs associated with at least one clinical variable, with the majority being associated with estradiol/progesterone levels. Functional enrichment implicated Wnt/mTOR pathways in embryo implantation and decidualization. Six DDE miRNAs were successfully replicated in the validation set, while the support vector machine (SVM) model achieved area under the curve (AUC) values of 0.816 (D0) and 0.870 (D3). Additionally, the association between hsa-miR-214-3p and its target gene CTNNB1 was further confirmed in Ishikawa cells. Conclusions: Understanding the dynamic landscape changes of the miRNA transcriptome in individuals with implantation failure will help identify dynamic biomarkers from ovulation to the post-implantation stage, providing new insights into the pathological mechanisms of implantation failure and facilitating the research and development of new therapies in the clinical setting.
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