Prolonged Renal Dysfunction in Patients Undergoing Chemotherapy for Locally Advanced Esophageal Cancer: Treatment Implications and Risk Factors.

Background/Aim: The effects of prolonged renal dysfunction in patients undergoing chemotherapy for locally advanced esophageal cancer remain unclear. This study retrospectively investigated its effects on treatment and identified associated risk factors. Patients and Methods: Patients with locally advanced esophageal squamous cell carcinoma who developed renal dysfunction during their initial chemotherapy with docetaxel, cisplatin, and 5-fluorouracil (DCF) were included. Patients with renal dysfunction were divided into two groups: prolonged and transient renal dysfunction groups. We assessed the effects of prolonged renal dysfunction on treatment outcomes and identified its risk factors using multivariate analysis. Results: Thirty patients were included in the prolonged renal dysfunction group and 38 in the transient group. The median relative dose intensity of cisplatin was 83.7% in the prolonged group and 95.1% in the transient group ( Conclusion: Prolonged renal dysfunction during DCF therapy for esophageal cancer reduces the relative dose intensity of cisplatin, potentially compromising survival. The pre chemotherapy serum creatinine level and urine volume on day 1 of the first cycle were identified as risk factors for prolonged renal dysfunction.