Evidence mapPaperPMID 41778408Full record

Trial reportAmerican journal of physiology. Endocrinology and metabolism2026

Acute interleukin-1β antagonism decreases systemic inflammation, increases GLP-1 release, and modulates insulin secretion in individuals with prediabetes.

Justus S Fischer, Matthias Hepprich, Marco Cattaneo, Lucia Seeger, Stefanie Dobler, Marc Y Donath

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Justus S FischerDepartment for Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0009-0004-0634-7723
Matthias HepprichDepartment for Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-6905-6235
Marco CattaneoDepartment for Clinical Research, University of Basel, Basel, Switzerland.ORCID 0000-0002-6610-8431
Lucia SeegerDepartment for Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefanie DoblerHospital Dornach, Dornach, Switzerland.
Marc Y DonathDepartment for Endocrinology, Diabetology and Metabolism, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-3143-5045

Funding

EC | HORIZON EUROPE Framework Programme (Horizon Europe) 101095433Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) 214900
6 · The paper itself

Abstract

Metabolic stress in obesity and diabetes activates innate immunity. Chronic IL-1β antagonism improves insulin secretion in type 2 diabetes. However, it is unclear how rapidly this effect occurs, whether it is also present in individuals with prediabetes, and if IL-1β influences GLP-1 secretion. Therefore, we acutely antagonized IL-1β in patients with prediabetes overnight. Two injections of anakinra significantly reduced total leucocyte count (

Indexed as

Glucagon-Like Peptide 1InflammationInsulin SecretionInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinPrediabetic StateAdultDouble-Blind MethodFemaleHumansInsulinInterleukin-6MaleMiddle AgedGlucagon-Like Peptide 1InsulinInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinInterleukin-6diabetesimmunologyinflammosomeobesity

Identifiers

PMID41778408
PMCPMC7618929

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.