ArticleArchives of Iranian medicine2025
Efficacy and Safety Analysis of Triple Therapy (Pabolizumab+Cryoablation+Renvastinib) for Patients with Unresectable Hepatocellular Carcinoma (uHCC).
Article in Archives of Iranian medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTo determine whether employing a monoclonal antibody against programmed death receptor-1 (PD-1) improves the safety and effectiveness of cryoablation used with Renvastinib to treat unresectable hepatocellular carcinoma (uHCC).
methodsOur study retrospectively enrolled 232 uHCC patients who were treated at our medical center between January 2019 and December 2023. Propensity score matching (PSM) was employed in this study for 1:1 matching, and 86 patients were matched in each group. Following matching, the two groups' negative events, and assessments were made on the objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). When comparing two groups, a group
resultsThe median follow-up period was 28 months. Forty deaths (46.0%) happened in the double group, whereas 33 deaths (38.0%) occurred in the triple group. The ORR and DCR of the triple treatment group were significantly higher than those of the double therapy group (ORR: 35.6% vs. 14.5%,
conclusionCompared with cryoablation combined with renvatinib, cryoablation combined with renvatinib and PD-1 mAb significantly improved the efficacy and survival of patients with uHCC without increasing adverse events, giving unresectable liver cancer a clinical foundation for treatment optimization.
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