Evidence map›Paper›PMID 41778427›Full record

ArticleArchives of Iranian medicine2025

Prognostic Significance of HMGA1 in Hepatocellular Carcinoma: Implications for Tumor Progression and Targeted Therapy.

Tianhao Tong, Bin Cheng, Wenhui Gao, Renyi Yang, Huiying Jian, Jingting Zhang, Zhuo Liu, Puhua Zeng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of Iranian medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianhao TongCancer Research Institute of Hunan Academy of Traditional Chinese Medicine, Hunan Academy of Chinese Medicine, Changsha, Hunan, China.ORCID 0000-0002-5371-386X
Bin ChengDepartment of Acupuncture, Xiangtan County Hospital of Traditional Chinese Medicine, Xiangtan, Hunan, China.ORCID 0009-0005-5063-2932
Wenhui GaoSchool of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Renyi YangSchool of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Huiying JianCancer Research Institute of Hunan Academy of Traditional Chinese Medicine, Hunan Academy of Chinese Medicine, Changsha, Hunan, China.
Jingting ZhangSchool of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Zhuo LiuDepartment of Scientific Research and Education, Hunan Provincial Hospital of Integrated Traditional Chinese and Western (The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine), Changsha, Hunan, China.ORCID 0000-0001-9235-5244
Puhua ZengCancer Research Institute of Hunan Academy of Traditional Chinese Medicine, Hunan Academy of Chinese Medicine, Changsha, Hunan, China.ORCID 0000-0001-6542-673X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh mobility group A1 (HMGA1) has emerged as a key oncogenic factor in various cancers, but its specific role in liver hepatocellular carcinoma (LIHC) remains incompletely understood. This study aimed to investigate the expression pattern, biological functions, immune associations, clinical relevance, and therapeutic potential of HMGA1 in LIHC.

methodsWe conducted a multi-omics analysis integrating transcriptomic, proteomic, and clinical data from TCGA, CPTAC, and HPA databases. Functional enrichment, immune infiltration profiling, and survival analyses were performed.

resultsHMGA1 was significantly overexpressed in LIHC at both mRNA and protein levels (

conclusionHMGA1 serves as a robust prognostic biomarker and functional driver of malignant progression in LIHC. Its integration into prognostic models may enhance risk stratification and guide personalized therapeutic strategies. Nevertheless, further

Indexed as

Carcinoma, HepatocellularHMGA1a ProteinLiver NeoplasmsBiomarkers, TumorCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMaleMiddle AgedPrognosisBiomarkers, TumorHMGA1a ProteinHMGA1 protein, humanCellular senescenceHMGA1Liver hepatocellular carcinomaPrognostic biomarkerTumor microenvironment

Identifiers

PMID41778427
PMCPMC12958422

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.