Evidence map›Paper›PMID 41779094›Full record

ArticleExperimental physiology2026

Seven days of warm-water immersion enhances resting irisin and BDNF, but not klotho, in older men.

Joel M Garrett, James J McCormick, Kelli E King, Kristina-Marie T Janetos, Nathalie V Kirby, Fergus K O'Connor, Glen P Kenny

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joel M GarrettSchool of Allied Health, Sport and Social Work, Griffith University, Queensland, Australia.
James J McCormickHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Kelli E KingHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Kristina-Marie T JanetosHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Nathalie V KirbyHuman and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
Fergus K O'ConnorSchool of Allied Health, Sport and Social Work, Griffith University, Queensland, Australia.ORCID https://orcid.org/0000-0001-9509-7682
Glen P KennyAustralian Centre for Precision Health and Technology (PRECISE), Griffith University, Gold Coast, Queensland, Australia.ORCID https://orcid.org/0000-0001-8683-6973

Funding

Human and Environmental Physiology Research UnitMitacs Accelerate Fellowship IT30924Natural Sciences and Engineering Council of Canada RGPIN-2020-03891University of Ottawa Industry Research Chair
6 · The paper itself

Abstract

We examined whether seven consecutive days of warm-water immersion could elevate resting and exercise-induced levels of brain-derived neurotrophic factor (BDNF), irisin and klotho in older adults. These biomarkers support cognitive and metabolic health, but their levels decline with age. Passive heat exposure, like warm-water immersion, may offer a promising alternative to exercise for enhancing cellular-level physiological resilience in populations where exercise is limited. Twelve habitually active older men (median [IQR] age: 68 [64-73] years;

Indexed as

ageingclimate changeheat stressmetabolic stressneuroplasticityoxidative stresspassive heatthermoregulation

Identifiers

PMID41779094
PMCPMC13394884

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.