Evidence map›Paper›PMID 41779360›Full record

ReviewStem cell reviews and reports2026

Targeting Endogenous Wnt Antagonists for Therapy Development in AGA: a Focus on DKKs and sFRPs.

Zhao Wang, Hui Bai, Siqi Wang, Sili Wang, Chunrong Yuan, Zonghuang Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhao WangDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.ORCID 0009-0000-6059-1648
Hui BaiDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Siqi WangDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Sili WangDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
Chunrong YuanDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China. 719230343@qq.com.
Zonghuang DingDepartment of Dermatology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, China. 10222299@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgenetic alopecia(AGA) is the most common form of hair loss worldwide. By middle age, approximately two-thirds of men and 40% of women are affected. The pathophysiology of AGA involves complex interactions among genetic predisposition, androgen sensitivity, and dysregulation of the hair follicles (HFs) cycle. Among the key regulatory pathways, the Wnt/β-catenin signaling pathway plays a central role in maintaining homeostasis of hair follicle stem cell (HFSCs) and dermal papilla cells (DPCs), as well as in promoting the transition to the anagen phase. Endogenous Wnt inhibitors, such as dickkopfs (DKKs) and secreted frizzled-related proteins (sFRPs), are upregulated under the influence of dihydrotestosterone and can modulate canonical Wnt signaling in DPCs and HFSCs via paracrine mechanisms, potentially contributing to the development of AGA. Targeted inhibition of these endogenous negative regulators may therefore represent a promising therapeutic strategy for AGA. This review summarizes current insights into the role of Wnt signaling in hair follicle biology, the characteristics and functions of DKKs and sFRPs in AGA, and their potential as therapeutic targets.

Indexed as

AlopeciaIntercellular Signaling Peptides and ProteinsMolecular Targeted TherapyWnt ProteinsWnt Signaling PathwayAnimalsFrizzled-Related ProteinsHair FollicleHumansStem CellsFrizzled-Related ProteinsIntercellular Signaling Peptides and ProteinsWnt ProteinsDermal papilla cellDickkopfHair regenerationPattern hair lossPrecision medicineSecreted frizzled-related proteinWnt signaling inhibitorWnt signaling pathway

Identifiers

PMID41779360

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.