Evidence map›Paper›PMID 41779670›Full record

ArticleACS synthetic biology2026

Benzylisoquinoline Alkaloid Production in Yeast via Norlaudanosoline Improves Titer, Selectivity, and Yield.

Lauren Narcross, Michael E Pyne, Kaspar Kevvai, Ka-Hei Siu, John E Dueber, Vincent J J Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lauren NarcrossDepartment of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada.
Michael E PyneDepartment of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada.ORCID 0009-0001-2878-9686
Kaspar KevvaiDepartment of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada.
Ka-Hei SiuDepartment of Bioengineering, University of California, Berkeley, Berkeley, California 94720, United States.
John E DueberDepartment of Bioengineering, University of California, Berkeley, Berkeley, California 94720, United States.ORCID 0000-0001-8404-7153
Vincent J J MartinDepartment of Biology, Concordia University, Montréal, Québec H4B 1R6, Canada.ORCID 0000-0001-7511-115X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The benzylisoquinoline alkaloid (BIA) family of tetrahydroisoquinolines (THIQs) comprises >2,500 members, including the pharmaceuticals morphine, codeine, and papaverine, as well as the antibiotics sanguinarine and chelerythrine. Agricultural cultivation can supply the demand for the BIAs that accumulate in plants, but broader access to the BIA family would facilitate additional research and commercialization. Microbial synthesis presents an attractive option due to cheap feedstock, genetic tractability, and ease of scale-up. Previously, we reported titers of the branch-point BIA (

Indexed as

AlkaloidsBenzylisoquinolinesSaccharomyces cerevisiaeAcetaldehydeFermentationIsoquinolinesMetabolic EngineeringAcetaldehydeAlkaloidsBenzylisoquinolinesIsoquinolinesreticulinebenzylisoquinoline alkaloidsmetabolic engineeringreticulineSaccharomyces cerevisiaesynthetic biologyyeast

Identifiers

PMID41779670
PMCPMC13010366

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.