ArticleJournal of aging and health2026
Young Adult Substance Use as a Predictor of Poor Self-Rated Memory Decades Later in Midlife.
Article in Journal of aging and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
ObjectivesWe examined longitudinal associations between young adult heavy substance use and late midlife poor self-rated memory and whether problematic substance use in early midlife mediated the associations.MethodsData were from the Monitoring the Future Longitudinal Panel Study. Analyses included individuals ages 50-65 in 2018-2023 who provided longitudinal data starting at age 18 in 1976-1991.ResultsYoung adult heavy use of all substances was directly associated with higher odds of late midlife poor self-rated memory. These associations were fully mediated by early midlife substance-use disorder symptoms for binge drinking and cannabis use, but not mediated for pack+/day cigarette smoking.DiscussionSustained heavy substance use in young adulthood appears to represent a cumulative risk factor for cognitive decline in late midlife. Examining risk factors, including substance use, across the life course may be crucial for earlier identification of risk for cognitive decline.
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