Evidence map›Paper›PMID 41779780›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Phosphatidylinositol 4,5-bisphosphate mediates Arl4D self-interaction to promote Pak1 signaling.

Ting-Wei Chang, Fang-Jen S Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ting-Wei ChangInstitute of Molecular Medicine, National Taiwan University College of Medicine, Taipei 10002, Taiwan.ORCID 0009-0002-9926-0672
Fang-Jen S LeeInstitute of Molecular Medicine, National Taiwan University College of Medicine, Taipei 10002, Taiwan.ORCID 0000-0002-2167-2426

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-association by small GTPases on membrane is critical for their signaling output and cellular function. However, a mechanistic understanding of how membrane components regulate this process remains incompletely understood. Here, we show that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

ADP-Ribosylation Factorsp21-Activated KinasesPhosphatidylinositol 4,5-DiphosphateSignal TransductionAnimalsCell MembraneCell MovementGuanosine TriphosphateHumansPhosphorylationProtein BindingADP-Ribosylation FactorsGuanosine Triphosphatep21-Activated KinasesPAK1 protein, humanPhosphatidylinositol 4,5-DiphosphateArf-like 4 GTPasecell migrationfibronectinPakPI(4,5)P2

Identifiers

PMID41779780
PMCPMC12974503

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.