Evidence map›Paper›PMID 41779795›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

NMI promotes the secretion of IL-17 and exacerbates psoriasis.

Yaqi Gao, Jingjing Wang, Zhen Qin, Na Xu, Xiaowen Wang, Tianqi Liu, Shengli Wang, Zhenxing Chen, Yunhua Xu, Yongjie Yao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yaqi Gao *School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Jingjing Wang *School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Zhen Qin *Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-1835-1453
Na Xu *Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Xiaowen WangDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China.
Tianqi LiuSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.ORCID 0009-0001-2771-3698
Shengli WangGuangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital (Zhuhai Clinical Medical College of Jinan University), Jinan University, Zhuhai, Guangdong 519000, China.
Zhenxing ChenShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Yunhua XuThe First Affiliated Hospital, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, China.ORCID 0000-0002-7610-5787
Yongjie YaoShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.
Yimiao WuShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.ORCID 0009-0003-5557-4458
Zhuangfeng WengShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.ORCID 0000-0002-7079-0293
Yan GengRheumatology and Clinical Immunology Department, Peking University First Hospital, Beijing 100034, China.
Zhinan YinThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong 510632, China.
Jing QinSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.
Tao XuZhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Yingfang LiuShenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases, School of Medicine, Sun Yat-sen University, Shenzhen 518107, China.ORCID 0000-0002-1835-0397
Huanhuan LiangSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China.ORCID 0000-0002-0285-2659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Damage-associated molecular patterns (DAMPs) are well established as key mediators of innate immune activation; however, their functions in modulating adaptive immunity, particularly T cell responses, remain incompletely characterized. Here, we report the identification and functional characterization of NMI-a recently identified DAMP-as a regulator of T helper 17 (Th17) cell activity and its involvement in psoriasis pathogenesis. Elevated expression of NMI was observed in psoriatic skin lesions and correlated significantly with heightened IL-17 levels. In a murine model of psoriasis,

Indexed as

Interleukin-17PsoriasisAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutSkinTh17 CellsToll-Like Receptor 4Il17f protein, mouseInterleukin-17Tlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID41779795
PMCPMC12974457

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.