Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Lubica Janovicova *Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.ORCID 0009-0002-9176-4593
Monika Janikova *Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.ORCID 0000-0002-5113-9673
Michal PastorekDepartment of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
Eva CsizmadiaDepartment of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
Cherith YoderDepartment of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
Alexandra LesayovaInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.ORCID 0009-0001-7073-8049
Liam GeyerDepartment of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
Vasileios C KyttarisDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.ORCID 0000-0001-7652-3826
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.ORCID 0000-0001-9589-2360
Peter CelecInstitute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.ORCID 0000-0001-5883-3580
Barbara WegielDepartment of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.ORCID 0000-0003-0679-8765
Funding
Characterizing the role of the heme catabolism in tissue damage and inflammation.R01DK125846 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEGIEL, BARBARA · 2021 to 2024
$2.1M
Role of biliverdin reductase during sterile inflammation in the liver.R01DK104714 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEGIEL, BARBARA · 2016 to 2020
$2.0M
Determining the role of gas metabolite in response to immunotherapyR21CA256720 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEGIEL, BARBARA · 2021 to 2022
$445k
Heme degradation pathway and immunomodulation in prostate cancer.R21CA169904 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI WEGIEL, BARBARA · 2013 to 2014
$411k
HHS | NIH | National Cancer Institute (NCI) CA256720HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK104714HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK125846Ministerstvo školstva, vedy, výskumu a športu SR | Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR (Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic for the Structural Funds of EU) APVV-22-0554NCI NIH HHS R21 CA169904NCI NIH HHS R21 CA256720NIDDK NIH HHS R01 DK104714NIDDK NIH HHS R01 DK125846
6 · The paper itself
Abstract
Hemolysis is associated with the release of damage-associated molecular patterns, including free heme and extracellular DNA (ecDNA). Using several mouse models of bleeding anemia and hemolysis, we demonstrate a significant increase in plasma ecDNA, independent of neutrophil extracellular trap formation. This ecDNA forms G-quadruplex (G4) structures, which we detected in both mice and patients with systemic lupus erythematosus. Catalytic complexes (DNAzymes) formed by G4 ecDNA and heme drive oxidative stress, tissue injury, and inflammation. In anemic mice lacking deoxyribonuclease 1L3 (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis. · full record | Socratic