Evidence map›Paper›PMID 41781358›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The relationships between ethnoracial identity, Aβ positivity, APOEε4, and medial temporal lobe tau PET.

Koral V Wheeler, Victoria R Tennant, Noelle N Lee, Maxwell W Hand, Suchita Ganesan, Patrick Walsh, Meral Tubi, Jamie A Terner, Brandon Hall, Marylan Davison and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The relationships between ethnoracial identity, Aβ positivity, APOEε4, and medial temporal lobe tau PET.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. APOE and amyloid-tau pathology in cognitively unimpaired older adults.Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Koral V WheelerMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Victoria R TennantMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Noelle N LeeMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Maxwell W HandMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Suchita GanesanMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Patrick WalshMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Meral TubiMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Jamie A TernerMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Brandon HallMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Marylan DavisonMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Arthur W TogaMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Sid O'BryantUniversity of North Texas Health Science Center Fort Worth Texas USA, Fort Worth, Texas, USA.
Alexandra L ClarkDepartment of Psychology, University of Texas at Austin, Austin, Texas, USA.
Kristine YaffeDepartment of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USA.
Meredith N BraskieMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
HABS‐HD Study Team

Funding

National Institute on Aging of the National Institutes of Health P41EB015922National Institute on Aging of the National Institutes of Health R01AG054073National Institute on Aging of the National Institutes of Health R01AG058533National Institute on Aging of the National Institutes of Health R01AG070862National Institute on Aging of the National Institutes of Health U19AG078109Office of The Director of the National Institutes of Health S10OD032285
6 · The paper itself

Abstract

introductionClarifying relationships between amyloid, tau, and cognition is crucial to understanding dementia risk, but has been mainly performed in non-Hispanic White (NHW) participants. It is unknown whether findings are generalizable to other ethnoracial groups.

methodsWe evaluated relationships between amyloid-β (Aβ) positivity, apolipoprotein E allele (APOE) ε4, tau-positron emission tomography (PET)

resultsBlack (β = 0.28, p < 0.001) and Hispanic (β = 0.34, p < 0.001) participants had higher medial temporal lobe (MTL) tau than NHW participants; however, findings were attenuated when accounting for choroid plexus off-target binding. Hispanic participants showed higher tau in lateral temporal regions compared to NHW and Black participants; however, reducing meningeal off-target binding through erosion demonstrated similar lateral temporal tau across groups. DISCUSSION: Factors other than amyloid and tau may impact cognition in Black participants. PI2620 off-target ethnoracial differences should be investigated.

Indexed as

Amyloid beta-PeptidesApolipoprotein E4Cognitive Dysfunctiontau ProteinsTemporal LobeAgedAged, 80 and overBlack or African AmericanFemaleHispanic or LatinoHumansMaleNeuropsychological TestsPositron-Emission TomographyWhiteAmyloid beta-PeptidesApolipoprotein E4tau Proteinsamyloid‐beta positivityAPOEε4ethnoracial identitylearning and memory performancemedial temporal lobetau PET imaging

Identifiers

PMID41781358
PMCPMC12960054

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.