Evidence map›Paper›PMID 41781614›Full record

ArticleNature2026

Genome modelling and design across all domains of life with Evo 2.

Garyk Brixi, Matthew G Durrant, Jerome Ku, Mohsen Naghipourfar, Michael Poli, Gwanggyu Sun, Greg Brockman, Daniel Chang, Alison Fanton, Gabriel A Gonzalez and 52 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 173 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

62 authors.

Garyk Brixi *Arc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-1253-0522
Matthew G Durrant *Arc Institute, Palo Alto, CA, USA.
Jerome Ku *Arc Institute, Palo Alto, CA, USA.
Mohsen Naghipourfar *Arc Institute, Palo Alto, CA, USA.
Michael Poli *Evo 2 Core Team, Palo Alto, CA, USA.
Gwanggyu Sun *Arc Institute, Palo Alto, CA, USA.
Greg BrockmanEvo 2 Core Team, Palo Alto, CA, USA.
Daniel ChangArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0003-0076-2833
Alison FantonArc Institute, Palo Alto, CA, USA.
Gabriel A GonzalezArc Institute, Palo Alto, CA, USA.
Samuel H KingArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-1260-5045
David B LiArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-8921-5168
Aditi T MerchantArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-9465-1351
Eric NguyenEvo 2 Core Team, Palo Alto, CA, USA.
Chiara Ricci-TamArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0000-0002-6549-1838
David W RomeroEvo 2 Core Team, Palo Alto, CA, USA.
Jonathan C SchmokArc Institute, Palo Alto, CA, USA.
Ali TaghibakhshiEvo 2 Core Team, Palo Alto, CA, USA.
Anton VorontsovEvo 2 Core Team, Palo Alto, CA, USA.
Brandon YangEvo 2 Core Team, Palo Alto, CA, USA.
Myra DengGoodfire, San Francisco, CA, USA.
Liv GortonGoodfire, San Francisco, CA, USA.ORCID http://orcid.org/0009-0009-7341-1517
Nam NguyenGoodfire, San Francisco, CA, USA.
Nicholas K WangGoodfire, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-1043-3072
Michael T PearceGoodfire, San Francisco, CA, USA.
Elana SimonGoodfire, San Francisco, CA, USA.
Etowah AdamsColumbia University, New York, NY, USA.
Zachary J AmadorUniversity of Washington, Seattle, WA, USA.
Euan A AshleyStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-9418-9577
Stephen A BaccusStanford University, Stanford, CA, USA.
Haoyu DaiStanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0008-4920-6815
Steven DillmannStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-4773-1463
Stefano ErmonStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-0039-2887
Daniel GuoArc Institute, Palo Alto, CA, USA.
Michael H HerschlArc Institute, Palo Alto, CA, USA.
Rajesh IlangoArc Institute, Palo Alto, CA, USA.
Ken JanikNVIDIA, Santa Clara, CA, USA.
Amy X LuUniversity of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-6575-7165
Reshma MehtaArc Institute, Palo Alto, CA, USA.
Mohammad R K MofradUniversity of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-7004-4859
Madelena Y NgStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3824-9349
Jaspreet PannuJohns Hopkins University, Baltimore, MD, USA.
Christopher RéStanford University, Stanford, CA, USA.
John St JohnNVIDIA, Santa Clara, CA, USA.
Jeremy SullivanArc Institute, Palo Alto, CA, USA.
Joseph TeyArc Institute, Palo Alto, CA, USA.ORCID http://orcid.org/0009-0002-6825-646X
Ben ViggianoStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1510-7567
Kevin ZhuUniversity of California, Berkeley, Berkeley, CA, USA.
Greg ZyndaNVIDIA, Santa Clara, CA, USA.ORCID http://orcid.org/0000-0003-4992-9614
Daniel BalsamGoodfire, San Francisco, CA, USA.
Patrick CollisonArc Institute, Palo Alto, CA, USA.
Anthony B CostaNVIDIA, Santa Clara, CA, USA.
Tina Hernandez-BoussardStanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-6553-3455
Eric HoGoodfire, San Francisco, CA, USA.
Ming-Yu LiuNVIDIA, Santa Clara, CA, USA.
Thomas McGrathGoodfire, San Francisco, CA, USA.
Kimberly PowellNVIDIA, Santa Clara, CA, USA.
Sudarshan PinglayEvo 2 Core Team, Palo Alto, CA, USA.
Dave P BurkeArc Institute, Palo Alto, CA, USA.
Hani GoodarziArc Institute, Palo Alto, CA, USA.
Patrick D HsuArc Institute, Palo Alto, CA, USA. patrick@arcinstitute.org.ORCID http://orcid.org/0000-0002-9380-2648
Brian L HieArc Institute, Palo Alto, CA, USA. brianhie@stanford.edu.ORCID http://orcid.org/0000-0003-3224-8142

Funding

INSTITUTIONAL TRAINING GRANT IN GENOME SCIENCET32HG000044 · NHGRI · STANFORD UNIVERSITY · PI MICHAEL P. SNYDER · 1995 to 2026
$32.2M
Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Dissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencingDP5OD036167 · OD · UNIVERSITY OF WASHINGTON · PI Sudarshan Pinglay · 2023 to 2026
$1.9M
NHGRI NIH HHS RM1 HG009491NHGRI NIH HHS T32 HG000044NIH HHS DP5 OD036167
6 · The paper itself

Abstract

All of life encodes information with DNA. Although tools for genome sequencing, synthesis and editing have transformed biological research, we still lack sufficient understanding of the immense complexity encoded by genomes to predict the effects of many classes of genomic changes or to intelligently compose new biological systems. Artificial intelligence models that learn information from genomic sequences across diverse organisms have increasingly advanced prediction and design capabilities

Indexed as

GenomeModels, GeneticAnimalsArtificial IntelligenceBinding SitesBRCA1 ProteinChromatinGenetic VariationGenomicsHumansMutationProkaryotic CellsBRCA1 ProteinChromatin

Identifiers

PMID41781614
PMCPMC13128491

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.