Evidence map›Paper›PMID 41781615›Full record

ArticleNature2026

The molecular basis of force selectivity by PIEZO2.

Eric M Mulhall, Oleg Yarishkin, Rose Z Hill, Anna K Koster, Ardem Patapoutian

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Yoda molecules agonize PIEZO2.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Eric M MulhallHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA. emulhall@scripps.edu.ORCID http://orcid.org/0000-0002-7018-2204
Oleg YarishkinHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-8215-7444
Rose Z HillHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-9558-6400
Anna K KosterHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA.
Ardem PatapoutianHoward Hughes Medical Institute, Department of Neuroscience, Dorris Neuroscience Center, Scripps Research, La Jolla, CA, USA. ardem@scripps.edu.ORCID http://orcid.org/0000-0003-0726-7034

Funding

Mechanisms of force sensing in the nervous systemR35NS105067 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM · 2018 to 2025
$6.1M
The Molecular Basis of PIEZO Ion Channel FunctionK99GM155547 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI MULHALL, ERIC MICHAEL · 2024 to 2025
$250k
NIGMS NIH HHS K99 GM155547NINDS NIH HHS R35 NS105067
6 · The paper itself

Abstract

PIEZOs are mechanically gated ion channels that transduce force into electrochemical signals

Indexed as

Ion Channel GatingIon ChannelsMechanotransduction, CellularActin CytoskeletonAnimalsFemaleFilaminsHEK293 CellsHumansMiceSingle Molecule ImagingFilaminsIon ChannelsPIEZO1 protein, humanPiezo1 protein, mousePIEZO2 protein, humanPiezo2 protein, mouse

Identifiers

PMID41781615
PMCPMC13149025

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.