ArticleScientific reports2026
Human stem cell-derived neurons establish functional inhibitory-excitatory cortical circuits in a chimeric transplantation model.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Excitation/inhibition balance is crucial to homeostatic brain function and disrupted in several neurodevelopmental and neurodegenerative diseases. Cortical inhibitory neurons derived from the medial ganglionic eminence (MGE) provide input to glutamatergic projection neurons, an essential function in neural processing. While neural grafts for stroke improve motor function following engraftment, these grafts typically contain only excitatory neurons (and glia), and little effort has been directed at understanding the role of inhibitory neurons in this context. Here, we generate a channelrhodopsin line to optogenetically control grafted human pluripotent stem cell-derived MGE interneurons in the context of a mixed inhibitory-excitatory chimeric transplantation model. We demonstrate robust differentiation toward either dorsal cortical excitatory or ventral MGE inhibitory fates. Co-grafts of inhibitory and excitatory neurons demonstrate lineage-specific maturation-predominantly excitatory CTIP2 + layer 5 projection neurons or inhibitory Calretinin + and SST+ interneurons. Co-grafts integrate and densely innervate both the graft and host tissues. We observed juxtaposition of excitatory and inhibitory fibres and synapses. Optogenetic stimulation confirmed that grafted inhibitory neurons are functionally integrated with grafted excitatory neurons, inducing inhibitory post-synaptic potentials, which were blocked with gabazine. Together, these data provide evidence of functional inhibitory-excitatory circuit reconstruction following transplantation and provide a platform for advanced cell therapies and disease modelling.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.