SynthesisHealth and quality of life outcomes2026
Psychometric properties of the health-related quality of life instrument with 8 items: a systematic review and meta-analysis.
Synthesis in Health and quality of life outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Validity of HINT-8 in evaluating health-related quality of life among cervical cancer patients.Journal of comparative effectiveness research · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Health-Related Quality of Life Instrument with 8 items (HINT-8) is a preference-based generic measure developed in 2014 for the Korean population. HINT-8 encompasses eight domains: climbing stairs, pain, vitality, working, depression, memory, sleep, and happiness. With the increasing use of HINT-8 in diverse research settings, a comprehensive synthesis is needed to clarify its psychometric performance and clinical utility. This study evaluated the properties of HINT-8 through a systematic review and meta-analysis.
methodsWe systematically searched PubMed, KoreaMed, KMbase, KISS, and Google Scholar for studies published from January 2019 to December 2024 reporting HINT-8 outcomes. Data on HINT-8 index scores and domain-level outcomes were extracted for quantitative synthesis. Four pooled analyses were conducted: (1) construct validity using correlation with EQ-5D and SF-36, (2) reliability using Cohen’s kappa and intraclass correlation coefficients, (3) overall and domain-specific ceiling effects based on response distributions, and (4) subgroup specific HINT-8 index scores across demographic and clinical characteristics. Random-effects meta-analyses were performed, and statistical heterogeneity was assessed using I² and τ² statistics.
resultsAmong the 70 studies reporting HINT-8 outcomes, 23 contributed to the quantitative synthesis. Lower HINT-8 index scores were observed among female, older adults, and individuals with lower socioeconomic status compared with their respective reference groups. Correlation coefficients demonstrated expected construct validity with higher correlations for similar domains. Distinct HINT-8 domains such as vitality, working, memory and sleep showed low correlations with EQ-5D or SF-36, reflecting its unique construct coverage. Reliability assessed by Cohen’s kappa ranged from 0.237 to 0.521 across domains, while intraclass correlation coefficients indicated substantial agreement. HINT-8 showed lower ceiling effects (5.4% [95%CI: 2.3–8.6]) than EQ-5D (41.0% [25.4–56.6]), indicating better discriminatory ability. HINT-8 index values showed clear differences across various health conditions and demographic factors.
conclusionWith enriched domains, HINT-8 demonstrated sensitivity and utility as a generic measure for capturing diverse health statuses when applied with established tariff-derived index scores. As all included studies were conducted in Korea, further validation in diverse settings is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.